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Association Between Age of Onset and Symptom Profiles of Late-Life Depression

Published online by Cambridge University Press:  16 April 2020

E. Corruble
E. Corruble*
Affiliation:
Paris XI University and INSERM U669, Kremlin Bicetre, France

Abstract

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Objective:

The recognition of later late-onset (LLO) major depression (MD) is a matter of concern.

Method:

Cross-sectional study assessed MD with the MINI structured interview and the MADRS in a referred sample of 13 377 non-demented adult out-patients visiting their physicians. Among 6850 patients with a first episode of MD, 370 LLO (75 years of age and older) MD were compared with 814 late-onset (LO) (60-74 years old) MD and 5666 early-onset (EO) (18-59 years old) MD.

Results:

There are many similarities between the symptom patterns of EO, LO and LLO MDs. However, the symptom pattern of LLO MD includes more retardation/agitation, lassitude, reduced appetite and apparent sadness, and less sleep disturbances, guilt feelings, pessimism and inner tension than LO and EO MD.

Conclusion:

The differences in symptom profiles are very modest and between-group differences may not be meaningful on an individual level.

Type
P01-239
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E627
Copyright
Copyright © European Psychiatric Association 2009
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