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Anxiety and Depressive Disorders in Middelage Subjects with Metabolic Syndrom

Published online by Cambridge University Press:  15 April 2020

N. Neznanov  and
V. Piotrovskaya
N. Neznanov
Affiliation:
Psychiatric department, First Pavlov Meaical University, St. Petersburg, Russia
V. Piotrovskaya
Affiliation:
Psychiatric department, First Pavlov Meaical University, St. Petersburg, Russia

Abstract

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Distinguish between the beginning of dementia and age-related changes in cognitive function is the primary task of research and, in turn, is an essential part of prevention of Alzheimer and vascular cognitive disorders. Mood disorders, apathy and anxiety are frequent in preclinical period of dementia. Dementia develops in 36% of cases after depression in elderly people . Metabolic syndrome (MS) is associated with an increased risk of developing a cardiac diseases, mood and cognitive disorders . We have examined the associations of depression (D), anxiety (A) and mild cognitive impairment (MCI) with the components of MS (lipid spectrum, glucose level (GL), insulin resistance) in middleage subjects.

Methods and results

Data was analyzed from 271 patients with MS according IDF criteria, (aged 30 – 60 years). Current D and A were confirmed according to the criteria of ICD-10. All patients passed through: MMSE, HADS, HARS, HAM-A tests. GL and plasma indicators of lipid spectrum were assessed using NCEP criteria.

Subjects were divided into 2 groups, group A – with D and/or A (139) and group B -without affective disorders (132). Using Mann-Whitney test significant connection between changes in levels of indicators of lipid spectrum, the GL and affective disorders in group A were obtained. Subjects with D and A and mild cognitive impairment (MCI) had higher level of VLDL and LDL-C in comparison with only MCI subjects.

Conclusion

There is link between affective disorders and components of MS. Increased level of LDL and VLDL provokes comorbidity of MCI, depression and anxiety.

Type
Article: 0183
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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