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Alteration of Cerebral Blood Flow Measured with SPECT in Patients with First Episode Psychosis

Published online by Cambridge University Press:  23 March 2020

P. Makarić
Affiliation:
University Psychiatric Hospital Vrapče, The Addictions Department, Zagreb, Croatia
D. Bošnjak
Affiliation:
University Psychiatric Hospital Vrapče, First Psychosis Unit, Zagreb, Croatia
I. Kekin
Affiliation:
Zagreb University Hospital Centre, Department of Psychiatry, Zagreb, Croatia
P. Jelacic
Affiliation:
University Psychiatric Hospital Vrapče, Department of Psychotic Disorders, Zagreb, Croatia
M. Haupert
Affiliation:
University Psychiatric Hospital Vrapče, Department of Psychotic Disorders, Zagreb, Croatia
N. Đuran
Affiliation:
University Psychiatric Hospital Vrapče, Department of Psychotic Disorders, Zagreb, Croatia
M. Sisek-Šprem
Affiliation:
University Psychiatric Hospital Vrapče, Department of Psychogeriatrics, Zagreb, Croatia
D. Perušić
Affiliation:
University Psychiatric Hospital Vrapče, Department of Psychotic Disorders, Zagreb, Croatia
P. Brečić
Affiliation:
University Psychiatric Hospital Vrapče, Department of Affective Disorders, Zagreb, Croatia
R. Petrović
Affiliation:
Zagreb University Hospital Centre, Department of nuclear medicine, Zagreb, Croatia
M. Rojnić Kuzman
Affiliation:
Zagreb University Hospital Centre, Department of Psychiatry, Zagreb, Croatia

Abstract

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Introduction

Single-photon emission computed tomography (SPECT) is a valid method for measuring regional cerebral blood flow (rCBF). Recent studies regarding rCBF in patients with first episode psychosis (FEP) reported heterogeneous results, but were limited with small sample size. Neuroimaging can help us in setting the diagnosis of illness, as well as in following the progress and finding more effective treatment for psychotic disorders.

Objectives

To compare, baseline alterations of the rCBF using SPECT with psychopathological status in FEP during acute phase.

Aims

To investigate the changes of rCBF in patients with FEP during acute phase.

Methods

We conducted a study on 40 drug – naïve patients with FEP at acute phase of illness during their hospitalization at Zagreb University hospital centre. The diagnosis was confirmed using diagnostic and statistical manual of mental disorders, fifth edition. rCBF was measured with SPECT and psychopathological status rated with the Positive and Negative Syndrome Scale.

Results

Our findings showed moderate to severe parieto-temporal perfusion deficits, mild to moderate parieto-fronto-temporal perfusion deficits or borderline perfusion deficits in all but one patient.

Conclusion

Our results showed alteration in rCBF at the beginning of the illness that indicate a biological market of psychotic disorder.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Walk: Schizophrenia and other psychotic disorders - Part 3
Copyright
Copyright © European Psychiatric Association 2017
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