Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-30T16:02:00.787Z Has data issue: false hasContentIssue false
  • English
  • Français

Age at onset in bipolar disorder: Investigation of the role of TaqIA polymorphism of DRD2 gene in a Sardinian sample

Published online by Cambridge University Press:  16 April 2020

A. Squassina ,
M. Manchia ,
M. Costa ,
C. Chillotti ,
R. Ardau ,
M. Del Zompo  and
G. Severino
A. Squassina*
Affiliation:
Laboratory of Molecular Genetics, Section of Clinical Pharmacology, Department of Neuroscience “B.B. Brodie”, University of Cagliari, Sp 8, Sestu-Monserrato, Km 0.700 Cagliari, Italy
M. Manchia
Affiliation:
Laboratory of Molecular Genetics, Section of Clinical Pharmacology, Department of Neuroscience “B.B. Brodie”, University of Cagliari, Sp 8, Sestu-Monserrato, Km 0.700 Cagliari, Italy Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
M. Costa
Affiliation:
Laboratory of Molecular Genetics, Section of Clinical Pharmacology, Department of Neuroscience “B.B. Brodie”, University of Cagliari, Sp 8, Sestu-Monserrato, Km 0.700 Cagliari, Italy
C. Chillotti
Affiliation:
Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy
R. Ardau
Affiliation:
Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy
M. Del Zompo
Affiliation:
Laboratory of Molecular Genetics, Section of Clinical Pharmacology, Department of Neuroscience “B.B. Brodie”, University of Cagliari, Sp 8, Sestu-Monserrato, Km 0.700 Cagliari, Italy Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy
G. Severino
Affiliation:
Laboratory of Molecular Genetics, Section of Clinical Pharmacology, Department of Neuroscience “B.B. Brodie”, University of Cagliari, Sp 8, Sestu-Monserrato, Km 0.700 Cagliari, Italy
*
*Corresponding author. Tel.: +39 070 675 4334; fax: +39 070 675 4320. E-mail address: squassina@unica.it (A. Squassina).
Get access

Abstract

Bipolar disorder (BD) is a highly heterogeneous and heritable psychiatric illness. Age at onset has been shown to be a powerful tool for dissecting both the phenotypic and genetic complexity of BD. In this article, we present findings from an association study between the DRD2 TaqIA polymorphism and age at onset, showing that both alleles and genotypes at this locus associate with early onset BD.

Keywords

Bipolar disorderAge at onsetDRD2TaqIAAdmixture analysis
Type
Short communication
Information
European Psychiatry , Volume 26 , Issue 3 , April 2011 , pp. 141 - 143
Copyright
Copyright © Elsevier Masson SAS 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

1

Contributed equally to the manuscript.

References

Bellivier, F, Golmard, JL, Henry, C, Leboyer, M, Schurhoff, FAdmixture analysis of age at onset in bipolar I affective disorder. Arch Gen Psychiatry 2001; 58: 510–512.CrossRefGoogle ScholarPubMed
Bellivier, F, Golmard, JL, Rietschel, M, Schulze, TG, Malafosse, A, Preisig, M, et al.Age at onset in bipolar I affective disorder: further evidence for three subgroups. Am J Psychiatry 2003; 160: 999–1001.CrossRefGoogle ScholarPubMed
Endicott, J, Spitzer, RLA diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 1978; 35: 837–844.CrossRefGoogle Scholar
Etain, B, Dumaine, A, Mathieu, F, Chevalier, F, Henry, C, Kahn, JP, et al.A SNAP25 promoter variant is associated with early-onset bipolar disorder and a high expression level in brain. Mol Psychiatry 2010; 15: 748–755.CrossRefGoogle Scholar
Etain, B, Mathieu, F, Rietschel, M, Maier, W, Albus, M, McKeon, P, et al.Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14. Mol Psychiatry 2006; 11: 685–694.CrossRefGoogle ScholarPubMed
Gauderman, WJ. Sample size requirements for association studies of gene-gene interaction. Am J Epidemiol 2002;155:478–84.CrossRefGoogle ScholarPubMed
Grandy, DK, Zhang, Y, Civelli, OPCR detection of the TaqA RFLP at the DRD2 locus. Hum Mol Genet 2 1993 2197CrossRefGoogle ScholarPubMed
Hamshere, ML, Gordon-Smith, K, Forty, L, Jones, L, Caesar, S, Fraser, C, et al.Age-at-onset in bipolar-I disorder: mixture analysis of 1369 cases identifies three distinct clinical sub-groups. J Affect Disord 2009; 116: 23–29.CrossRefGoogle ScholarPubMed
Jonsson, EG, Nothen, MM, Grunhage, F, Farde, L, Nakashima, Y, Propping, P, et al.Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Mol Psychiatry 1999; 4: 290–296.CrossRefGoogle ScholarPubMed
Lafuente, A, Bernardo, M, Mas, S, Crescenti, A, Aparici, M, Gasso, P, et al.Polymorphism of dopamine D2 receptor (TaqIA, TaqIB, and-141C Ins/Del) and dopamine degradation enzyme (COMT G158A, A-278G) genes and extrapyramidal symptoms in patients with schizophrenia and bipolar disorders. Psychiatry Res 2008; 161: 131–141.CrossRefGoogle ScholarPubMed
Laruelle, M, Gelernter, J, Innis, RBD2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene. Mol Psychiatry 1998; 3: 261–265.CrossRefGoogle Scholar
Leboyer, M, Henry, C, Paillere-Martinot, ML, Bellivier, FAge at onset in bipolar affective disorders: a review. Bipolar Disord 2005; 7: 111–118.CrossRefGoogle ScholarPubMed
Li, T, Liu, X, Sham, PC, Aitchison, KJ, Cai, G, Arranz, MJ, et al.Association analysis between dopamine receptor genes and bipolar affective disorder. Psychiatry Res 1999; 86: 193–201.CrossRefGoogle ScholarPubMed
Lin, PI, McInnis, MG, Potash, JB, Willour, V, MacKinnon, DF, DePaulo, JR, et al.Clinical correlates and familial aggregation of age at onset in bipolar disorder. Am J Psychiatry 2006; 163: 240–246.CrossRefGoogle ScholarPubMed
Lin, PI, McInnis, MG, Potash, JB, Willour, VL, MacKinnon, DF, Miao, K, et al.Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q. Am J Hum Genet 2005; 77: 545–555.CrossRefGoogle ScholarPubMed
Manchia, M, Lampus, S, Chillotti, C, Sardu, C, Ardau, R, Severino, G, et al.Age at onset in Sardinian bipolar I patients: evidence for three subgroups. Bipolar Disord 2008; 10: 443–446.CrossRefGoogle ScholarPubMed
Massat, I, Lerer, B, Souery, D, Blackwood, D, Muir, W, Kaneva, R, et al.HTR2C (cys23ser) polymorphism influences early onset in bipolar patients in a large European multicenter association study. Mol Psychiatry 2007; 12: 797–798.CrossRefGoogle Scholar
Massat, I, Souery, D, Del Favero, J, Van Gestel, S, Serretti, A, Macciardi, F, et al.Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders. Am J Med Genet B Neuropsychiatr Genet 2002; 114: 177–185.CrossRefGoogle Scholar
Nothen, MM, Erdmann, J, Korner, J, Lanczik, M, Fritze, J, Fimmers, R, et al.Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder. Am J Psychiatry 1992; 149: 199–201.Google ScholarPubMed
Pohjalainen, T, Rinne, JO, Nagren, K, Lehikoinen, P, Anttila, K, Syvalahti, EK, et al.The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. Mol Psychiatry 1998; 3: 256–260.CrossRefGoogle ScholarPubMed
Serretti, A, Smeraldi, EDopamine D2 receptor gene not associated with symptomatology of mood disorders. Am J Med Genet B Neuropsychiatr Genet 1999; 88: 294–297.3.0.CO;2-H>CrossRefGoogle ScholarPubMed
Severino, G, Manchia, M, Contu, P, Squassina, A, Lampus, S, Ardau, R, et al.Association study in a Sardinian sample between bipolar disorder and the nuclear receptor REV-ERBalpha gene, a critical component of the circadian clock system. Bipolar Disord 2009; 11: 215–220.CrossRefGoogle Scholar
Spitzer, RL, Endicott, J, Robins, E. Research Diagnostic criteria for a Selected Group of Functional Disorders. New York:New York State Psychiatric Institute; 1977.Google Scholar
Submit a response

Comments

No Comments have been published for this article.