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Tolerability and side effects of an extended-release injectable suspension of aripripazole in a series of inpatients in a dual diagnosis unit

Published online by Cambridge University Press:  23 March 2020

A. Palma
Affiliation:
Parc de Salut Mar. Institut Hospital del Mar d’Investigacions Mèdiques-IMIM-UAB, Institut de Neuropsiquiatria i Addiccions, Barcelona, Spain
G. Mateu
Affiliation:
Parc de Salut Mar. Institut Hospital del Mar d’Investigacions Mèdiques-IMIM-UAB, Institut de Neuropsiquiatria i Addiccions, Barcelona, Spain
J.L. Perez de Heredia
Affiliation:
Parc de Salut Mar. Institut Hospital del Mar d’Investigacions Mèdiques-IMIM-UAB, Institut de Neuropsiquiatria i Addiccions, Barcelona, Spain
R. Martinez
Affiliation:
Parc de Salut Mar. Institut Hospital del Mar d’Investigacions Mèdiques-IMIM-UAB, Institut de Neuropsiquiatria i Addiccions, Barcelona, Spain
C. Castillo
Affiliation:
Parc de Salut Mar. Institut Hospital del Mar d’Investigacions Mèdiques-IMIM-UAB, Institut de Neuropsiquiatria i Addiccions, Barcelona, Spain
M.G. Hurtado
Affiliation:
Parc de Salut Mar. Institut Hospital del Mar d’Investigacions Mèdiques-IMIM-UAB, Institut de Neuropsiquiatria i Addiccions, Barcelona, Spain
J. Martí
Affiliation:
Parc de Salut Mar. Institut Hospital del Mar d’Investigacions Mèdiques-IMIM-UAB, Institut de Neuropsiquiatria i Addiccions, Barcelona, Spain
R. Sanchez
Affiliation:
Parc de Salut Mar. Institut Hospital del Mar d’Investigacions Mèdiques-IMIM-UAB, Institut de Neuropsiquiatria i Addiccions, Barcelona, Spain
M.T. Campillo
Affiliation:
Parc de Salut Mar. Institut Hospital del Mar d’Investigacions Mèdiques-IMIM-UAB, Institut de Neuropsiquiatria i Addiccions, Barcelona, Spain
M. Torrens
Affiliation:
Parc de Salut Mar. Institut Hospital del Mar d’Investigacions Mèdiques-IMIM-UAB, Institut de Neuropsiquiatria i Addiccions, Barcelona, Spain
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Abstract

Introduction

The integrated care in dual diagnosis units involves selecting pharmacological treatment strategies for both substance use disorder and the non-addictive psychiatric disorder. It is recommended to choose drugs with a favorable balance between efficacy/tolerability, an adequate side effects profile and the minimal drug interactions.

Objectives and aims

To evaluate the tolerability and side effects after first administration-first dose of an extended-release injectable suspension of aripiprazole in a group of patients admitted to an acute dual diagnosis unit.

Methods

The study included a series of patients admitted in our unit from May to August 2015 that received the first dose of the aripiprazole preparation (400 mg). Evaluations included different scales for side effects (SAS, ESRS, UKU) and the clinical global impression scale (CGI).

Results

A total of 9 patients were included and evaluated (all men, mean age: 39-years-old). Diagnoses were: bipolar disorder (5/9), schizophrenia (2/9), schizoaffective disorder (1/9) and delusional disorder (1/9) with concomitant substance use disorder (6 cannabis, 2 alcohol, 1 cocaine). All of them without outpatient control and treatment at admission. The results of the clinical scales conclude that none of them had significant side effects, including extrapyramidal, with an improvement in the ICG scale.

Conclusion

Tolerability of extended-release injectable suspension of aripiprazole was good in all cases. In the future, new cases should be included to extend the sample and to evaluate other aspects such as the craving for substances.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EV1009
Copyright
Copyright © European Psychiatric Association 2016

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Tolerability and side effects of an extended-release injectable suspension of aripripazole in a series of inpatients in a dual diagnosis unit
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