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Quality of life in schizophrenia and bipolar disorder: The impact of symptomatic remission and resilience

Published online by Cambridge University Press:  23 March 2020

A. Hofer
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
Y. Mizuno
Affiliation:
Keio University School of Medicine, Department of Neuropsychiatry, Tokyo, Japan Institute of Psychiatry, Psychology and Neuroscience, King's College London, Department of Psychosis Studies, London, UK
F. Wartelsteiner
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
W. Wolfgang Fleischhacker
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
B. Frajo-Apor
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
G. Kemmler
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
M. Mimura
Affiliation:
Keio University School of Medicine, Department of Neuropsychiatry, Tokyo, Japan
S. Pardeller
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
C. Sondermann
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
T. Suzuki
Affiliation:
Keio University School of Medicine, Department of Neuropsychiatry, Tokyo, Japan
A. Welte
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
H. Uchida
Affiliation:
Keio University School of Medicine, Department of Neuropsychiatry, Tokyo, Japan
Corresponding
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Abstract

Background:

Health-related quality of life (HRQOL) is significantly affected in individuals with schizophrenia or bipolar I disorder (BD-I). The current study investigated whether symptomatic remission and resilience might differently impact HRQOL in these patients.

Methods:

Fifty-two patients with schizophrenia and 60 patients suffering from BD-I from outpatient mental health services as well as 77 healthy control subjects from the general community were included into a cross-sectional study. HRQOL and resilience were assessed using the WHOQOL-BREF and the Resilience Scale. In patients, psychopathology was quantified by the Positive and Negative Syndrome Scale or the Montgomery Asberg Depression Rating Scale and the Young Mania Rating Scale, respectively.

Results:

Notably, both patient groups showed lower HRQOL and resilience compared to control subjects, non-remitted patients indicated lower HRQOL than remitted ones. The effect of remission on HRQOL was significantly larger in patients with BD-I than in those with schizophrenia but did not explain the difference in HRQOL between groups. Resilience predicted HRQOL in all three groups. When accounting for the effect of resilience among remitted patients, only the difference in HRQOL between schizophrenia patients and control subjects was significant.

Conclusion:

These findings demonstrate the impact of symptomatic remission and resilience on HRQOL of both patients suffering from schizophrenia and BD-I and indicate that these factors are especially relevant for HRQOL of patients with BD-I.

Type
Original article
Copyright
Copyright © European Psychiatric Association 2017

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