Skip to main content Accessibility help
×
Home
Hostname: page-component-544b6db54f-rcd7l Total loading time: 0.132 Render date: 2021-10-17T18:31:17.768Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

Article contents

P0179 - Prospective, multicenter, open-label, observational study of sexual function in patients beginning aripiprazole treatment

Published online by Cambridge University Press:  16 April 2020

A.L. Montejo
Affiliation:
Hospital Universitario de Salamanca, Salamanca, Spain
M.C. Campos
Affiliation:
Complejo Hospitalario de San Millan, Logrono, Spain
C. Fombellida
Affiliation:
Hospital Universitario de Salamanca, Salamanca, Spain
M. Franco
Affiliation:
Centro de Salud Miguel Armijo, Salamanca, Spain
J. Garcia Mellado
Affiliation:
Centro de Salud Miguel Armijo, Salamanca, Spain
A. Perez Urnaiz
Affiliation:
Hospital de Meixoeiro, Vigo, Spain
J.M. Olivares
Affiliation:
Medical Department, Bristol-Myers Squibb, Madrid, Spain
M.A. Ortega
Affiliation:
Complejo Hospitalario de San Millan, Logrono, Spain
N. Prieto
Affiliation:
Hospital Universitario de Salamanca, Salamanca, Spain
Y. Riesgo
Affiliation:
Otsuka Pharmaceuticals, Barcelona, Spain
I. Barber
Affiliation:
Otsuka Pharmaceuticals, Barcelona, Spain
Get access

Abstract

Objectives:

Antipsychotic treatment is known to be associated with secondary sexual dysfunction (SD). Recognition and treatment of this adverse effect has received growing attention. Until now, all antipsychotic agents were thought to potentially cause SD mediated by increased prolactin. Our aim was to observe whether aripiprazole modifies SD in patients with schizophrenia after 3 months of treatment.

Material and Methods:

Multicenter, observational, open-label, prospective, three-month study with single group of aripiprazole treated patients. Sexual activity was assessed using CGI-S and CGI-I for SD; SALSEX scale, validated for Spanish, 3 times after initiating study drug. Patient's clinical status was evaluated by CGI-S and CGI-I for psychotic disorders, and by BPRS Scale.

Result: 42 patients (70% men), 38 completed the study. Incidence of SD at 3 months was null for all patients studied. As period of treatment advanced, the Salsex score decreased, showing a mean overall reduction of –5 points (SD 3.6). Largest reduction was observed in subgroup of patients with SD in baseline visit, who exhibited a mean reduction of –6 points (SD 3.1).

Men with SD in baseline evaluation showed more marked improvement than women at 40 days of treatment (p=0.0447). However, recovery was similar for both groups at 90 days of treatment.

Conclusions:

In schizophrenia, SD secondary studies to antipsychotics are important in establishing effectiveness of these agents in chronic treatment. After 3 months of aripiprazole treatment, no SD was observed in patients. Patients who presented SD at study initiation improved over course of 3 months treatment with aripiprazole.

Type
Poster Session I: Schizophrenia and Psychosis
Copyright
Copyright © European Psychiatric Association 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)
Submit a response

Comments

No Comments have been published for this article.

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

P0179 - Prospective, multicenter, open-label, observational study of sexual function in patients beginning aripiprazole treatment
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

P0179 - Prospective, multicenter, open-label, observational study of sexual function in patients beginning aripiprazole treatment
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

P0179 - Prospective, multicenter, open-label, observational study of sexual function in patients beginning aripiprazole treatment
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *