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P0120 - Oxidative cell damage is related to the enlargement of the lateral ventricles in children and adolescents with first episode schizophrenia

Published online by Cambridge University Press:  16 April 2020

D. Fraguas
Affiliation:
Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain
S. Reig
Affiliation:
Department of Experimental Medicine, Hospital General Universitario Gregorio Maranon, Madrid, Spain
M. Desco
Affiliation:
Department of Experimental Medicine, Hospital General Universitario Gregorio Maranon, Madrid, Spain
O. Rojas-Corrales
Affiliation:
Department of Neurosciences, College of Medicine, University of Cadiz, Cadiz, Spain
J. Gibert-Rahola
Affiliation:
Department of Neurosciences, College of Medicine, University of Cadiz, Cadiz, Spain
M. Parellada
Affiliation:
Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain
D. Moreno
Affiliation:
Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain
J. Castro-Fornieles
Affiliation:
Department of Child and Adolescent Psychiatry and Psychology, Institut Clinic of Neurosciences, IDIBAPS, (Institut D Investigacions Biomediques August Pi Sunyer), Hospital Clinic Universitari of Barcelona, Barcelona, Spain
M. Graell
Affiliation:
Section of Child and Adolescent Psychiatry and Psychology, Hospital Infantil Universitario Niño Jesus, Madrid, Spain
I. Baeza
Affiliation:
Department of Child and Adolescent Psychiatry and Psychology, Institut Clinic of Neurosciences, IDIBAPS, (Institut D Investigacions Biomediques August Pi Sunyer), Hospital Clinic Universitari of Barcelona, Barcelona, Spain
A. Gonzalez-Pinto
Affiliation:
Stanley Institute International Mood Disorders Research Center, 03-RC-003, Hospital Santiago Apostol, Vitoria, Spain
S. Otero
Affiliation:
Child and Adolescent Mental Health Unit, Department of Psychiatry and Psychology, Hospital Universitario Marques de Valdecilla, Santander, Spain
C. Arango
Affiliation:
Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain
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Abstract

Background:

Brain volume abnormalities and oxidative cell damage have been reported to be pathological characteristics of schizophrenia patients. This study aims to assess a potential relationship between these two characteristics in child and adolescent patients with first-episode psychosis.

Method:

26 child and adolescent patients with first-episode early-onset schizophrenia, and 78 age- and gender-matched healthy controls were assessed. Magnetic resonance imaging (MRI) scans were used for volumetric measurements of five cerebral regions: gray matter of the frontal, parietal, and temporal lobes, sulcal cerebrospinal fluid (CSF), and lateral ventricles. Oxidative cell damage was traced by means of a systemic increase in lipid hydroperoxides (LOOH).

Results:

Lateral ventricle volumes were significantly higher in schizophrenia patients than in controls. In schizophrenia patients, a significant positive relationship was found between oxidative cell damage (LOOH levels) and the abnormal enlargement of the lateral ventricles, after controlling for total intracranial volume, age, gender, daily smoking status, intelligence quotient (IQ), psychopathology, and time since onset of psychotic symptoms. No association was found between brain volumes and oxidative cell damage in control subjects.

Conclusions:

Our results suggest that, in patients with first-episode early-onset schizophrenia, enlargement of the lateral ventricles is associated with chronic oxidative cell damage.

Type
Poster Session I: Schizophrenia and Psychosis
Copyright
Copyright © European Psychiatric Association 2008

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