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Is there an association between the COMT gene and P300 endophenotypes?

Published online by Cambridge University Press:  16 April 2020

E. Bramon
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
E. Dempster
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
S. Frangou
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
C. McDonald
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
P. Schoenberg
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
J.H. MacCabe
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
M. Walshe
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
P. Sham
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
D. Collier
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
R.M. Murray
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
Corresponding
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Abstract

P300 wave anomalies correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The COMT gene is thought to influence cognitive performance and to be a susceptibility gene for schizophrenia. Unlike two previous studies, we found no significant influence of the COMT gene on P300 amplitude or latency in 189 individuals examined. The well-supported role of the COMT gene both in dopamine catabolism as well as in prefrontal cognition makes a strong theoretical case for the influence of COMT Val158Met polymorphism on P300 endophenotypes. However, the available neurophysiologic evidence suggests that any such association, if present, must be very subtle.

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Original article
Copyright
Copyright © Elsevier SAS 2006

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Is there an association between the COMT gene and P300 endophenotypes?
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