Skip to main content Accessibility help
×
Home
Hostname: page-component-564cf476b6-scc96 Total loading time: 0.184 Render date: 2021-06-21T00:31:57.952Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true }

Article contents

Interactions between mephedrone and alcohol in humans: Cardiovascular and subjective effects

Published online by Cambridge University Press:  23 March 2020

M. Farré
Affiliation:
Hospital Universitari Germans Trias i Pujol-IGTP-IMIM-UAB, Clinical Phamacology, Badalona, Spain
C. Perez-Maña
Affiliation:
Hospital del Mar Medical Research Institute-IMIM-UAB and UPF, Human Pharmacology, Badalona, Spain
E. de Souza
Affiliation:
Faculty of Psychology and Neuroscience, Maastricht University, Neuropsychology and Psychopharmacology, Maastricht, Netherlands
J. Mateus
Affiliation:
Hospital del Mar Medical Research Institute-IMIM-UAB and UPF, Human Pharmacology, Badalona, Spain
E. Theunisen
Affiliation:
Faculty of Psychology and Neuroscience, Maastricht University, Neuropsychology and Psychopharmacology, Maastricht, Netherlands
K. Kuypers
Affiliation:
Faculty of Psychology and Neuroscience, Maastricht University, Neuropsychology and Psychopharmacology, Maastricht, Netherlands
J. Ramaekers
Affiliation:
Faculty of Psychology and Neuroscience, Maastricht University, Neuropsychology and Psychopharmacology, Maastricht, Netherlands
F. Fonseca
Affiliation:
Institut de Neuropsiquiatria i Addiccions, Parc de Salut Mar-IMIM-UAB, Addiction Unit, Badalona, Spain
M. Torrens
Affiliation:
Institut de Neuropsiquiatria i Addiccions, Parc de Salut Mar-IMIM-UAB, Addiction Unit, Badalona, Spain
E. Olesti
Affiliation:
Hospital del Mar Medical Research Institute-IMIM-UAB and UPF, Human Pharmacology, Badalona, Spain
R. de la Torre
Affiliation:
Hospital del Mar Medical Research Institute-IMIM-UAB and UPF, Human Pharmacology, Badalona, Spain
E. Papaseit
Affiliation:
Hospital del Mar Medical Research Institute-IMIM-UAB and UPF, Human Pharmacology, Badalona, Spain
Get access

Abstract

Introduction

Mephedrone is a synthetic cathinone derivative included in the class of “New-Novel Psychoactive Substances”. Synthetic cathinones are marketed as “bath salts” or “plant food” and gained notable popularity for similar effects to 4-methylenedioxymethamphetamine (MDMA, ecstasy), or amphetamines. Mephedrone is commonly consumed simultaneously with alcohol.

Objectives and aims

The aim of the present study was to evaluate the interactions between mephedrone and ethanol in humans.

Methods

Twelve healthy male, recreational users of psychostimulants participated as outpatients in four experimental sessions. They received a single oral dose of mephedrone (200 mg) and alcohol (0.8 g/kg), mephedrone placebo and alcohol (0.8 g/kg), mephedrone (200 mg) and placebo alcohol, and both placebos. Design was double-blind, double-dummy, randomized, cross-over and controlled with placebo. Study variables included: vital signs (blood pressure, heart rate, temperature, and pupil diameter), subjective effects (visual analogue scales-VAS, ARCI-49 item short form, and VESSPA questionnaire).

Results

The combination produced an increase in the cardiovascular effects of mephedrone and induced more intense feeling of euphoria and well-being in comparison to mephedrone and alcohol. Mephedrone reduced the drunkenness and sedation produced by alcohol.

Conclusions

These results are similar to those obtained with the combination of other psychostimulants as amphetamines and MDMA. Abuse liability of the combination is greater that induced by mephedrone.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EW04
Copyright
Copyright © European Psychiatric Association 2016

Access options

Get access to the full version of this content by using one of the access options below.
Submit a response

Comments

No Comments have been published for this article.
3
Cited by

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Interactions between mephedrone and alcohol in humans: Cardiovascular and subjective effects
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Interactions between mephedrone and alcohol in humans: Cardiovascular and subjective effects
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Interactions between mephedrone and alcohol in humans: Cardiovascular and subjective effects
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *