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Elevated plasma levels of lipoprotein(a) in psychiatric patients: a possible contribution to increased vascular risk

Published online by Cambridge University Press:  16 April 2020

Enzo Emanuele*
Affiliation:
Molecular Medicine Laboratory, Clinica Medica 2, IRCCS Policlinico San Matteo, University of Pavia, Piazzale Golgi, 2, 27100 Pavia, Italy
Maria V. Carlin
Affiliation:
Servizio Psichiatrico di Diagnosi e Cura, IRCCS Policlinico San Matteo, ASL, University of Pavia, Pavia, Italy
Angela D’Angelo
Affiliation:
Molecular Medicine Laboratory, Clinica Medica 2, IRCCS Policlinico San Matteo, University of Pavia, Piazzale Golgi, 2, 27100 Pavia, Italy
Emmanouil Peros
Affiliation:
Molecular Medicine Laboratory, Clinica Medica 2, IRCCS Policlinico San Matteo, University of Pavia, Piazzale Golgi, 2, 27100 Pavia, Italy
Francesco Barale
Affiliation:
Servizio Psichiatrico di Diagnosi e Cura, IRCCS Policlinico San Matteo, ASL, University of Pavia, Pavia, Italy
Diego Geroldi
Affiliation:
Molecular Medicine Laboratory, Clinica Medica 2, IRCCS Policlinico San Matteo, University of Pavia, Piazzale Golgi, 2, 27100 Pavia, Italy
Pierluigi Politi
Affiliation:
Servizio Psichiatrico di Diagnosi e Cura, IRCCS Policlinico San Matteo, ASL, University of Pavia, Pavia, Italy
*
*Corresponding author. Tel.: +39 0382 50 2092; fax: +39 0382 52 6259. E-mail address:lab.genmolcl@smatteo.pv.it (E. Emanuele).
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Abstract

An increased incidence of adverse cardiovascular events has been reported in psychiatric patients, but the exact mechanisms underlying this association are still uncertain. Elevated plasma level of lipoprotein(a) [Lp(a)] is an independent risk factor for atherothrombotic disease in the general population. To study the implications of Lp(a) in psychiatric patients, we measured the plasma levels of Lp(a) in 74 patients with psychiatric disorders (39 schizophrenia, 10 major depression, 13 bipolar disorder and 12 personality disorder) and 74 healthy controls. The Lp(a) levels of the patient groups with schizophrenia, major depression and bipolar disorder were significantly higher than that of the control group. The median Lp(a) value of these diagnostic groups was comparable with those reported in patients with prior atherothrombotic events. On the other hand, no differences were found among personality disorder and controls. Our findings suggest that the elevation of plasma Lp(a) may contribute to increased cardiovascular risk in several patients with psychiatric disorders.

Type
Original article
Copyright
Copyright © Elsevier SAS 2006

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