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Disturbance of serum albumin conformation in patients with melancholic depression

Published online by Cambridge University Press:  23 March 2020

M. Uzbekov*
Affiliation:
Moscow Research Institute of Psychiatry, Brain Pathology, Moscow, Russia
T. Syrejshchikova
Affiliation:
Lebedev Physical Institute, High energy, Moscow, Russia
N. Smolina
Affiliation:
Federal Research and Clinical Center of Physical-Chemical Medicine, Biophysical methods of diagnostics, Moscow, Russia
V. Brilliantova
Affiliation:
Moscow Research Institute of Psychiatry, Brain Pathology, Moscow, Russia
G. Dobretsov
Affiliation:
Federal Research and Clinical Center of Physical-Chemical Medicine, Biophysical methods of diagnostics, Moscow, Russia
V. Krujkov
Affiliation:
Moscow Research Institute of Psychiatry, Affective disorders, Moscow, Russia
I. Emel’yanova
Affiliation:
Moscow Research Institute of Psychiatry, Affective disorders, Moscow, Russia
V. Krasnov
Affiliation:
Moscow Research Institute of Psychiatry, Affective disorders, Moscow, Russia
*
*Corresponding author.
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Abstract

Introduction

The last years it is became clear that disturbances in molecular processes in pathological conditions can be connected with conformational changes in protein structure.

Aim

Investigation of blood albumin conformation in patients with melancholic depression.

Material and methods

There were investigated 19 patients with melancholic depression (12 women and 7 men) and 25 health volunteers. Patient's state according to ICD-10 criteria was defined as a depressive episode in the frame of bipolar depressive disorder (type 2) (F32) and in the structure of recurrent depressive disorder (F33). Subnanosecond laser time resolved fluorescence spectroscopy (SLTRFS) (subnanosecond diapason) with K-35 fluorescent probe was used for the investigation of albumin conformation.

Results and discussion

There were revealed 3 binding sites in albumin molecule with fluorescent decay time of 1, 3 and 9 nanoseconds (A1, A3 and A9 sites, respectively) in healthy volunteers using SLTRFS approach. There were found significant differences between albumin binding sites of volunteers and patients with melancholic depression, respectively, А1–117 ± 7 и 142 ± 10; А3–358 ± 14 и 420 ± 26; А9–371 ± 16 и 433 ± 29.

Conclusion

These findings point out that melancholic depression is followed by conformational changes of albumin molecule that can affect its functional properties. We can hypothesized that albumin binding properties can serve as a biomarker of the efficacy of psychopharmacotherapy.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EW195
Copyright
Copyright © European Psychiatric Association 2016

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