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2129 – Abnormal Functional Connectivity Of Amygdala In Late Onset Depression Was Associated With Cognitive Deficits, But Not With Depressive Severity

Published online by Cambridge University Press:  15 April 2020

Y. Yue
Affiliation:
Southeast University, Nanjing
Y. Yuan
Affiliation:
Affiliated ZhongDa Hospital and Institute of Neuropsychiatry of Southeast University, Nanjing
Z. Hou
Affiliation:
The 4th People's Hospital of Wuhu City, Wuhu, China
W. Jiang
Affiliation:
Southeast University, Nanjing
F. Bai
Affiliation:
Affiliated ZhongDa Hospital and Institute of Neuropsychiatry of Southeast University, Nanjing
Z. Zhang
Affiliation:
Affiliated ZhongDa Hospital and Institute of Neuropsychiatry of Southeast University, Nanjing
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Abstract

Background

Major depressive disorder (MDD) is associated with abnormal functional connectivity (FC) of amygdala and decreased function of cortico-limibic circuit, which play important roles in the pathogenesis of MDD. However, little is known about the connectivity alterations in late-onset depression (LOD), and whether such disrupted function is correlated with cognitive impairment is unclear.

Methods

A total of twenty-three LOD patients and thirty-seven controls underwent neuropsychological tests and resting-state functional magnetic resonance imaging (RS-fMRI). Regional homogeneity (ReHo) and FC of bilateral amygdala seed were used to analyze blood oxygen level-dependent fMRI data between groups.

Results

Compared to controls, LOD groups showed weaker functional activity in bilateral middle frontal gyrus and left medial orbitofrontal gyrus, moreover, the decreased ReHo was positively correlated with Trail making test-B score (TMTB, r= 0.462,P= 0.04). In aspects of FC, left amygdala has reduced FC with right fusiform gyrus, right superior temporal gyrus and right putamen, while right amygdala has reduced FC with left cerebellum. Further correlative analysis found that the decreased FC between amygdala and right putamen was positively correlated with Verbal fluency test-verb score (VFT-verb, r= 0.513,P= 0.021) and the decreased FC between amygdala and superior temporal gyrus was positively correlated with Auditory Verbal Memory Test-delayed recall score (AVLT-delayed recall, r= 0.446,P= 0.049).

Conclusions

Our finding of reduced activation of prefrontal gyrus as well as decreased connection of bilateral amygdala may be key factors of impaired cognitive function in LOD patients and these changes could be early indicator for cognitive deficits.

Type
Research Article
Copyright
Copyright © European Psychiatric Association 2012

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