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1267 – Functional Polymorphism In The Interleukin-6 Gene (il-6 Rs1800795), And Depression Induced By Interferon-alpha And Ribavirin During The Hcv Treatment

Published online by Cambridge University Press:  15 April 2020

K.M. Małyszczak ,
D.A. Frydecka ,
T. Pawłowski  and
M. Inglot
K.M. Małyszczak
Affiliation:
Department of Psychiatry, Division of Psychotherapy and Psychosomatic Medicine
D.A. Frydecka
Affiliation:
Department of Psychiatry, Clinic of Psychiatry
T. Pawłowski
Affiliation:
Department of Psychiatry, Division of Psychotherapy and Psychosomatic Medicine
M. Inglot
Affiliation:
Department and Clinic of Infectious Diseases, Hepatology and Acquired Immune Deficiencies, Wroclaw Medical University, Wroclaw, Poland

Abstract

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Introduction

The inflammatory response system is important in the pathophysiology of depressive symptoms that are frequent side effects of interferon-alpha (IFN-alpha) treatment. The functional rs1800795 IL-6 promoter SNP [-174 IL-6 (G > C)] has been described, with ‘CC’ genotype associated with lower synthesis of IL-6.

Objectives

The present study was carried out to determine whether rs1800795 IL-6 polymorphism is associated with severity of depression developed during IFN-alpha and ribavirin treatment.

Methods

We included 54 Caucasian patients receiving pegylated IFN-alpha and ribavirin treatment for chronic hepatitis C virus infection in the prospective cohort study. Symptoms of depression (Montgomery - Åsberg Depression Rating Scale, MADRS, Beck Depression Inventory, BDI) and neuroticism (Eysenck Personality Questionnaire - Revised, EPQ-R/N) were assessed before treatment, just after treatment and 24 weeks after treatment.

Results

The mean MADRS ratings were higher in subjects with genotype ‘CC’ (p> 0.1). On the other hand, the BDI and EPQR/ N ratings were higher, and more stable in patients with ‘GG’ genotype (p> 0.1). Higher changes and the lowest values 24 weeks after the end of treatment were associated with ‘CC’ genotype (p< 0.05). The mean values were as follows (begin, end of treatment, 24 weeks after treatment): MADRS ‘CC’ (8.7, 11.3, 4.8), ‘GG’ (6.9, 11.1, 6.0); BDI ‘CC’ (6.9, 8.9, 3.2), ‘GG’ (8.4, 11.3, 6.2); EPQ-R/N ‘CC’ (8.3, 10.1, 7.3), ‘GG’ (10.4, 10.9, 9.2).

Conclusions

Genotype ‘CC’ of IL-6 rs1800795 polymorphism is associated with bigger differences in BDI and EPQ-R/N ratings during IFN-alpha and ribavirin treatment, and lower ratings after treatment.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E621
Copyright
Copyright © European Psychiatric Association 2013
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