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Respuesta subjetiva disfórica a los neurolépticos en la esquizofrenia: relación con los efectos secundarios extrapiramidales y los síntomas

Published online by Cambridge University Press:  12 May 2020

M. Gervin ,
S. Browne ,
J. Garavan ,
M. Roe ,
C. Larkin  and
E. O'Callaghan
M. Gervin
Affiliation:
The Theodore and Vada Stanley Research Unit, Cluain Mhuire Service, Hospitaller Order St John of God, Blackrock, Co. Dublin, Irlanda
S. Browne
Affiliation:
The Theodore and Vada Stanley Research Unit, Cluain Mhuire Service, Hospitaller Order St John of God, Blackrock, Co. Dublin, Irlanda
J. Garavan
Affiliation:
The Theodore and Vada Stanley Research Unit, Cluain Mhuire Service, Hospitaller Order St John of God, Blackrock, Co. Dublin, Irlanda
M. Roe
Affiliation:
The Theodore and Vada Stanley Research Unit, Cluain Mhuire Service, Hospitaller Order St John of God, Blackrock, Co. Dublin, Irlanda
C. Larkin
Affiliation:
The Theodore and Vada Stanley Research Unit, Cluain Mhuire Service, Hospitaller Order St John of God, Blackrock, Co. Dublin, Irlanda
E. O'Callaghan
Affiliation:
The Theodore and Vada Stanley Research Unit, Cluain Mhuire Service, Hospitaller Order St John of God, Blackrock, Co. Dublin, Irlanda
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Resumen

Objetivo:

Los informes subjetivos de respuestas disfóricas a la medicación neuroléptica son comunes en la práctica clínica. Sin embargo, los efectos secundarios cognitivos y afectivos de las medicaciones neurolépticas son difíciles de diferenciar de los síntomas de esquizofrenia. Tratamos de dilucidar la contribución relativa de los efectos secundarios extrapiramidales y los síntomas a la respuesta disfórica.

Método:

Se evaluó a 50 pacientes ambulatorios estables clínicamente con esquizofrenia que asistían a un centro de rehabilitación en cuanto a los efectos secundarios extrapiramidales y los síntomas antes de completar el inventario de actitud hacia los medicamentos (DAI).

Resultados:

La presencia de efectos secundarios extrapiramidales, encontrados en 28 pacientes (Z = -1,99, p = 0,05), y la gravedad de los síntomas negativos (r = -0,47, p = 0,001) se asociaban independientemente con la respuesta disfórica, explicando una proporción significativa de la varianza (R = 0,53, R2 = 25,2%, F = 9,27, gl = 2, p = 0,0004).

Conclusiones:

Los pacientes que comunican una respuesta disfórica que ellos asocian con las medicaciones neurolépticas tienen más efectos secundarios extrapiramidales y síntomas negativos más graves. Aunque estas respuestas pueden ser parte de los síntomas negativos de la enfermedad o deberse a otros factores como la depresión, planteamos la posibilidad de que puedan ser clínicamente indistinguibles del llamado "síndrome de déficit inducido por neurolépticos" y una medida subjetiva de él.

Keywords

disforiaextrapiramidalneurolépticosesquizofreniasíntomas
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 7 , Issue 3 , April 2000 , pp. 181 - 185
Copyright
Copyright © European Psychiatric Association 2000

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