Hostname: page-component-848d4c4894-mwx4w Total loading time: 0 Render date: 2024-06-15T18:33:33.144Z Has data issue: false hasContentIssue false

Polimorfismo del gen del receptor de tipo 2A para la serotonina (5HTR2A) y rasgos de la personalidad en pacientes con psicosis mayores

Published online by Cambridge University Press:  12 May 2020

V.E. Golimbet
Affiliation:
Laboratorio de Genética Preventiva, Centro de Investigación en Salud Mental, Academia Rusa de Ciencias Médicas, Zagorodnoe sh. 2/2, Moscú, Rusia113152
M.V. Alfimova
Affiliation:
Laboratorio de Genética Preventiva, Centro de Investigación en Salud Mental, Academia Rusa de Ciencias Médicas, Zagorodnoe sh. 2/2, Moscú, Rusia113152
K.K. Manandyan
Affiliation:
Laboratorio de Genética Preventiva, Centro de Investigación en Salud Mental, Academia Rusa de Ciencias Médicas, Zagorodnoe sh. 2/2, Moscú, Rusia113152
N.G. Mitushina
Affiliation:
Laboratorio de Genética Preventiva, Centro de Investigación en Salud Mental, Academia Rusa de Ciencias Médicas, Zagorodnoe sh. 2/2, Moscú, Rusia113152
L.L. Abramova
Affiliation:
Laboratorio de Genética Preventiva, Centro de Investigación en Salud Mental, Academia Rusa de Ciencias Médicas, Zagorodnoe sh. 2/2, Moscú, Rusia113152
V.G. Kaleda
Affiliation:
Laboratorio de Genética Preventiva, Centro de Investigación en Salud Mental, Academia Rusa de Ciencias Médicas, Zagorodnoe sh. 2/2, Moscú, Rusia113152
I.V. Oleichik
Affiliation:
Laboratorio de Genética Preventiva, Centro de Investigación en Salud Mental, Academia Rusa de Ciencias Médicas, Zagorodnoe sh. 2/2, Moscú, Rusia113152
YuB. Yurov
Affiliation:
Laboratorio de Genética Preventiva, Centro de Investigación en Salud Mental, Academia Rusa de Ciencias Médicas, Zagorodnoe sh. 2/2, Moscú, Rusia113152
V.I. Trubnikov
Affiliation:
Laboratorio de Genética Preventiva, Centro de Investigación en Salud Mental, Academia Rusa de Ciencias Médicas, Zagorodnoe sh. 2/2, Moscú, Rusia113152
Get access

Resumen

Se ha comunicado que el polimorfismo del gen del receptor para la serotonina (5HTR2A) se asocia con fenotipos clínicos en la esquizofrenia. El estudio actual intentó investigar una relación entre el polimorfismo 102T/C del 5HTR2A y los rasgos de la personalidad así como los síntomas clínicos en pacientes con diagnóstico de la CIE-10 de esquizofrenia y trastornos afectivos. Se administró la determinación del genotipo del 5HTR2A, la evaluación clínica y psicológica a 375 pacientes, 104 familiares sanos en primer grado de los pacientes y 157 controles. Se observó en los pacientes una asociación entre el genotipo 2/2 del 5HTR2A y las puntuaciones en la escala de Hipocondría (MMPI) (ANOVA, F = 4,56; P = 0,011) y la ansiedad como rasgo (F = 4,21; P = 0,002). Se ha encontrado también una diferencia significativa entre los genotipos 1/1 y 2/2 para las puntuaciones de Neuroticismo (EPI) (f = 2,18; P = 0,0031). No se observaron diferencias significativas según el genotipo del 5HTR2A en el grupo de control o de familiares en primer grado para todas las escalas estudiadas. Los síntomas positivos, negativos y psicopatológicos se elevaban más en los pacientes con el genotipo 2/2 comparado con los portadores de otros genotipos. Por tanto, el genotipo 2/2 puede contribuir a producir el fenotipo, con rasgos clínicos y patológicos específicos en común, con independencia de la heterogeneidad nosológica de las psicosis.

Type
Artículo original

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bibliografía

Arranz, MSErdmann, JKirov, GRietschel, MSodhi, MAlbus, M, et al.5-HTR2A receptor and bipolar affective disoder: association studies in affected patients. Neurosci Lett 1997;224:95-8.CrossRefGoogle Scholar
Arranz, MJMunro, JSham, PKirov, GMurray, RMCollier, DA, et al.Meta-analysis of studies on genetic variation in 5-HTR2a receptors and clozapine response. Schizophr Res 1998;32:93-9.CrossRefGoogle Scholar
Beresin, FBMiroshnikov, MPRojanez, RV.The Multiple Personality Inventory. Moscow: Medicine; 1976.Google Scholar
Butcher, JN, Ed. MMPI: Research developments and clinical application. New York: Mcgraw-Hill; 1969.Google Scholar
Chen, CHLee, YRWei, FCKoong, FJHwu, HGHsiao, KJ.Lack of allelic association between 102 T/C polymorphism of serotonin receptor type 2A gene and schizophrenia in Chinese. Psychiatr Genet 1997;1:35-8.CrossRefGoogle Scholar
Du, LBakish, DRavindran, AVLapierre, YDAnishman, HHrdina, PD.An association of 5-HTR2A receptor, serotonin transponer, and tryptophan hydroxylase gene polymorphisms in major depression. Am J Med Genet 1998;81:A522.Google Scholar
Enoch, MAKaye, WHHarris, CVirkkunen, MGoldvman, D.Personality traits associated with the 5-HTR2A promoter polymorphism,-1438GA. Mol Psychiatry 1999;4(Suppl. 1):89.CrossRefGoogle Scholar
Erdmann, JShimron-Abarbanell, DRietschel, MAlbus, MMaier, WKorner, J, et al.Systematic screening for mutations in the human serotonin 2A(5HT2A) receptor gene identification of two naturally occurring receptor variants and association analysis in schizophrenia. Hum Genet 1996;97:614-9.CrossRefGoogle Scholar
Evans, JBattersby, SOgilvie, ADSmith, CAHarmar, AJNutt, DJ, et al.Association of short alleles of a VNTR of the serotonin transponer gene with anxiety symptoms in patients presenting after deliberate self-harm. Neuropharmacology 1997;36:439-44.CrossRefGoogle Scholar
Eysenck, HJEysenck, SBG.Manual for Eysenck Personality Inventory. San Diego: Educational and Industrial Testing Setvice; 1968.Google Scholar
Hanin, YuL.Study of anxiety in sports. Voprosi Psichologii (Psychological Questions [in Russian]) 1978; N6-. 94-106.Google Scholar
Harrison, PJBurnet, PW.The 5-HT2a (serotonin 2A) receptor gene in the aetiology, pathophysiology and pharmacotherapy of schizophrenia. J Psychopharmacol 1997;11:18-20.CrossRefGoogle Scholar
Hawi, ZMyakishev, MVStraub, REO’Neill, NKendler, KSWalsh, D, et al.No association or linkage between the 5-HT2a T 102C polymorphism and schizophrenia in Irish families. Am J Med Genet 1997;74:370-3.3.0.CO;2-T>CrossRefGoogle ScholarPubMed
He, ILi, TMelville, CLiu, SFeng, GYGu, NF, et al.102 T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations. Am J Med Genet 1999;88:95-8.3.0.CO;2-O>CrossRefGoogle ScholarPubMed
Hrdina, PDBakish, DRavindran, AChudzik, JCavazzoni, PLapierre, YD.Platelet serotonergic Indices in major depression: up-regulation of 5-HT2A receptors unchanged by antidepressant treatment. Psychiatry Res 1997;66:73-85.CrossRefGoogle ScholarPubMed
Golimbet, VEManandyan, KKAbramova, LIOrlova, VAKaleda, VGOleichik, IV, et al.5HTR2A gene polymorphism and negative symptoms in patients with schizophrenia and schizophrenia spectrum disorders. Mol Psychiatry 1999;4(Supp 1.1):90.Google Scholar
Golimbet, VEManandyan, KKAbramova, LIOrlova, VAKaleda, VGOleichik, IV, et al.5-HTR2A gene polymorphism and some clinical and pathogenetic characteristics in patients with schizophrenia and schizophrenia spectrum disorders. Korsakov J Neurol Psychiatry 2000;100:36-9.Google Scholar
Gottesman, IIShields, J.MMPI twin study. Schizophrenia and genetics. New York: Academic Press; 1972. p. 259-89.Google Scholar
Inayama, YYoneda, HSakai, T, Ishida. T, Nonomura, YTakahata, K, et al.Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia. Am J Med Genet 1996;67:103-5.3.0.CO;2-S>CrossRefGoogle Scholar
Joober, RBendelfat, CBrisebois, KToulouse, ATurecki, GLal, S, et al.T102C polymorphism in the 5HTR2A gene and schizophrenia: relation to phenotype and drug response variability. J Psychiatry Neurosci 1999;24:141-6.Google Scholar
Kay, SRFiszbein, AOpler, LA.Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull 1987;13:261-76.CrossRefGoogle Scholar
Lesch, KPBengel, DHeils, ASabol, SZGreenberg, BDPetri, S, et al.Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-31.CrossRefGoogle ScholarPubMed
Lin, CUTsai, SJYu, YWSong, HLTu, PCSin, CB, et al.No evidence for association of serotonin 2A receptor variant (102T/C) with schizophrenia or clozapine response in a Chinese population. Neuroreport 1999;10:57-60.CrossRefGoogle ScholarPubMed
Masselis, MBasile, VMeltzer, HYLieberman, JASevy, SMacciardi, IM, et al.Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients. Neuropsychopharmacology 1998;19:123-32.CrossRefGoogle Scholar
Rusalov, VM.New adopted version of Eysenck Personality Inventory. J Psychology (in Russian) 1987;8:113-26.Google Scholar
Shinkai, TOhmori, OKojima, HTerao, TSujuki, TAbe, K.Negative association between T102C polymorphism of the 5-HTR2A receptor gene and schizophrenia in Japan. Hum Hered 1998;48:212-5.CrossRefGoogle Scholar
Schmidt, CJSorensen, SMKehne, JHCarr, AAPalfreyman, MJ.The role of 5-HT2A receptors in antipsychotic activity. Life Sci 1995;56:2209-22.CrossRefGoogle ScholarPubMed
Spurlock, GHeils, AHolmans, PWilliams, JD’Souja, UMCardno, A, et al.A family based association study of T102C polymorphism in 5HTR2A and schizophrenia plus identification of new polymorphisms in the promoter. Mol Psychiatry 1998;2:42-9.CrossRefGoogle Scholar
Staner, LHilger, CHentges, FMonreal, JHoffmann, ACouturier, M, et al.Association between Novelty-Seeking and the Dopamine D3 receptor gene in bipolar patients: A preliminary report. Am J Med Gen 1998;81:192-4.3.0.CO;2-C>CrossRefGoogle ScholarPubMed
Subotnik, KLNuechterlein, KHVentura, J.MMPI discriminators of deficit vs non-deficit recent-onset schizophrenia patients. Psychiatr Res 2000;93:111-23.CrossRefGoogle ScholarPubMed
Verga, MMacciardi, FCohen, SPedrini, SSmeraldi, E.No association between schizophrenia and the serotoin receptor 5HTR2A in an Italian population. Am J Med Genet 1997;74:21-5.3.0.CO;2-Y>CrossRefGoogle Scholar
Warren, JTPeacock, MLRodrigues, LCFink, AG.An Mspl polymorphism in the human serotonin receptor gene (5HTR2A): Detection by DGGE and FLP analysis. Hum Mol Genet 1993;2:338.CrossRefGoogle Scholar
Williams, JSpurlock, GMcGuffin, PMallet, JNothen, MMGill, M, et al.Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene, European Multicentre association study of Schizophrenia (EMASS) Group. Lancet 1996;347:9011.CrossRefGoogle ScholarPubMed