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Frecuencia de la apolipoproteína E-ɛ4, en la esquizofrenia de déficit

Published online by Cambridge University Press:  12 May 2020

F. Thibaut
Affiliation:
Unidad de Genética Molecular (Unidad INSERM EPI 9906), IFR 23, CHU de Rouen
A. Van der Elst
Affiliation:
Unidad de Genética Molecular (Unidad INSERM EPI 9906), IFR 23, CHU de Rouen
D. Campion
Affiliation:
Unidad de Genética Molecular (Unidad INSERM EPI 9906), IFR 23, CHU de Rouen
C. Martin
Affiliation:
Unidad de Genética Molecular (Unidad INSERM EPI 9906), IFR 23, CHU de Rouen
B. Coron
Affiliation:
Grupo de Investigación en Psicopatología y Esquizofrenias (JE2014), Facultad de Medicina de Rouen y Caen, Rouen, Francia
S. Dollfus
Affiliation:
Grupo de Investigación en Psicopatología y Esquizofrenias (JE2014), Facultad de Medicina de Rouen y Caen, Rouen, Francia
T. H. Frebourg
Affiliation:
Unidad de Genética Molecular (Unidad INSERM EPI 9906), IFR 23, CHU de Rouen
M. Petit
Affiliation:
Unidad de Genética Molecular (Unidad INSERM EPI 9906), IFR 23, CHU de Rouen
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Resumen

Se ha encontrado que el genotipo de la apolipoproteína E (ApoE) afecta a la expresión de varios trastornos neuropsiquiátricos. Determinamos las frecuencias del genotipo de la ApoE y su relación con los síntomas negativos primarios en 61 pacientes esquizofrénicos sin déficit y 45 con déficit, y los comparamos con 98 sujetos de control. No se observaron diferencias cuando se compararon las frecuencias del genotipo o de los alelos entre los tres grupos. Nuestros datos no apoyan la existencia de un papel para la ApoE en la expresión fenotípica de la esquizofrenia.

Type
Artículo original
Copyright
Copyright © European Psychiatric Association 2000

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