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Distribución estacional de los nacimientos en pacientes con la enfermedad de Alzheimer y pacientes depresivos mayores

Published online by Cambridge University Press:  12 May 2020

U. Ptok ,
A. Papassotiropoulos ,
W. Maier  and
R. Heun
U. Ptok
Affiliation:
Departamento de Psiquiatría, Universidad de Bonn, Sigmund-Freud-St. 2553105, Bonn, Alemania
A. Papassotiropoulos
Affiliation:
Departamento de Psiquiatría, Universidad de Bonn, Sigmund-Freud-St. 2553105, Bonn, Alemania
W. Maier
Affiliation:
Departamento de Psiquiatría, Universidad de Bonn, Sigmund-Freud-St. 2553105, Bonn, Alemania
R. Heun
Affiliation:
Departamento de Psiquiatría, Universidad de Bonn, Sigmund-Freud-St. 2553105, Bonn, Alemania
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Resumen

Los nacimientos en invierno se han asociado con un riesgo más elevado de enfermedad de Alzheimer (EA) y otros trastornos psiquiátricos. En la presente investigación, se examinó esta asociación putativa en una muestra de pacientes gerontopsiquiátricos. Un análisis de las tasas de nacimiento trimestrales de 83 pacientes con EA, 78 pacientes depresivos mayores con comienzo temprano del trastorno depresivo y 74 pacientes con comienzo tardío, 48 pacientes con EA y depresión a la vez (pacientes comórbidos) y 107 sujetos de control sanos no reveló una distribución estacional particular para ninguno de los grupos diagnósticos. En los pacientes con EA y comórbidos, controlar el genotipo de la ApoE no cambió este hallazgo. El análisis de regresión matemática reveló los hallazgos esperados de que la mayor edad y la presencia del alelo ApoE4 se asociaban con un riesgo más elevado de demencia. La menor edad y el género femenino se identificaron como factores de riesgo para trastorno depresivo. Haber nacido en invierno (en los tres primeros meses del aflo) no se asociaba con ninguno de los subgrupos diagnóstics. Concluimos que, en nuestra muestra, no se encontró que una distribución estacional de los nacimientos aumentara el riesgo para EA o depresión geriátrica.

Keywords

enfermedad de Alzheimergenotipo de la ApoEdepresión en la persona mayorestación de nacimiento
Type
Artículo Original
Information
European Psychiatry (Ed. Española) , Volume 8 , Issue 6 , September 2001 , pp. 378 - 383
Copyright
Copyright © European Psychiatric Association 2001

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References

Bibliografía

Andreasen, NC, Endicott, J, Spitzer, RL, Winokur, G. The family history method using diagnostic criteria. Arch Gen Psychiatry 1977; 34: 1229–35.CrossRefGoogle ScholarPubMed
Boyd, JH, Pulver, AE, Stewart Season of birth: schizophrenia and bipolar disorder. Schizophr Bull 1986; 12: 173–86.CrossRefGoogle Scholar
Bradbury, TN, Miller, GA. Season of birth in schizophrenia: a review of evidence, methodology and etiology. Psychol Bull 1985; 98: 569–94.CrossRefGoogle ScholarPubMed
Castrogiovanni, P, Iapichino, S, Pachhierotti, C, Pieraccini, F. Season of birth in psychiatry. A review. Neuropsychobiology 1998; 37: 175–81.CrossRefGoogle Scholar
Dysken, MW, Kuskowski, M, Skare, SS, Roessmann, U, Noronha, A, Frey, WH 2d. Seasonal distribution of births in Alzheimer’s disease. Int Psychogeriatr 1991; 3: 53–8.CrossRefGoogle ScholarPubMed
Fratiglioni, L, Ahlbom, A, Viitanen, M, Winblad, B. Risk factors for late-onset Alzheimer’s disease: a population based, case control study. Ann Neurol 1993; 33: 258–66.CrossRefGoogle ScholarPubMed
Fratiglioni, L, Viitanen, M, von, Strauss E, Tontodonatí, V, Herlitz, A, Winblad, B. Very oíd women at highest risk of dementia and Alzheimer’s disease: incidence data from the Kungsholmen project, Stockholm. Neurology 1997; 48: 132–8.CrossRefGoogle Scholar
Gao, S, Hendrie, HC, Hall, KS, Hui, S. The relationships between age, sex, and the incidence of dementia and Alzheimer’s disease. Arch Gen Psychiatry 1998; 55: 809–15.CrossRefGoogle Scholar
Haré, EH. Mental disorder and season of birth: a rational sample compared with the general population. Br J Psychiatry 1974; 124: 81–6.CrossRefGoogle Scholar
Haré, EH. Manic-depressive psychosis and season of birth. Acta Psychiatr Scand 1975; 52: 69–79.CrossRefGoogle ScholarPubMed
Henderson, AS, Korten, AE, Jorm, AF, McCusker, E, Creasy, H, Broe, GA. Season of birth for Alzheimer’s disease in the southern hemisphere. Psychol Med 1991; 21: 371–4.CrossRefGoogle ScholarPubMed
Heun, R, Hardt, J, Müller, H, Maier, W. Selection bias during recruitment of elderly subjects from the general population for psychiatric interviews. Eur Arch Psychiatry Clin Neurosci 1997; 247: 87–92.CrossRefGoogle ScholarPubMed
Jorm, AF, Jolley, D. The incidence of dementia. A metaanalysis. Neurology 1998; 51: 728–33.CrossRefGoogle ScholarPubMed
Modestin, J, Ammann, R, Würmle, O. Season of birth: comparison of patients with schizophrenia, affective disorders and alcoholism. Acta Psychiatr Scand 1995; 91: 140–3.CrossRefGoogle ScholarPubMed
Payami, H, Montee, K, Grimslid, H, Shattuc, S, Kaye, J. Increased risk of familial late-onset Alzheimer’s disease in Neurology 1996; 46: 126–9.Google Scholar
Philpot, M, Rottenstein, M, Burns, A, Der, G. Season of birth in Alzheimer’s disease. Br J Psychiatry 1989; 155: 662–6.CrossRefGoogle ScholarPubMed
Prince, M, Cullen, M, Mann, A. Risk factors for Alzheimer’s disease and dementia: A case-control study based on the MRC elderly hypertension trial. Neurology 1994; 44: 97–104.Google ScholarPubMed
Prince, MJ, Harwood, RH, Thomas, A, Mann, AH. A prospective population-based cohort study of the effects of disablement and social milieu on the onset and maintenance of late-life depression. Psychol Med 1998; 25: 337–50.CrossRefGoogle Scholar
Rhimer, Z. Season of birth and season of hospital admission in bipolar depressed female patients. Psychiatry Res 1980; 3: 247–51.CrossRefGoogle Scholar
Robins, LN, Helzer, JC, Weissman, MM, Orvaschel, H, Gruenberg, E, Burke, JD, et al. Lifetime prevalence of specific psychiatric disorders in three sites. Arch Gen Psychiatry 1984; 41: 949–58.CrossRefGoogle ScholarPubMed
Saunders, AM, Strittmatter, WJ, Schmechel, D, George-Hyslop, PH, Pericak-Vanee, MA, Joo, SH, et al. Association of apolipoprotein E alíele epsilon 4 with late-onset familial and sporadic Alzheimer’s disease. Neurology 1993; 43: 1467–72.CrossRefGoogle Scholar
St, Clair D, Rennie, M, Slorach, E, Norrman, J, Yates, C, Carothers, A. Apolipoprotein E epsilon 4 alíele is a risk factor for familial and sporadic persenile Alzheimer’s disease in both homozygote and heterozygote carriers. J Med Genet 1995; 32: 642–4.Google Scholar
Torrey, EF, Miller, J, Rawlings, R, Yolken, RH. Seasonality of births in schizophrenia and bipolar disorder: a review of the literature. Schizophr Res 1997; 28: 1–38.CrossRefGoogle ScholarPubMed
Vezina, H, Houde, L, Charbonneau, H, Beaudry, M, Cholette, A, Daoud, N, et al. Season of birth and Alzheimer’s disease: a population-based study in Saguenay-Lac-St-Jean/Quebec (IMAGE Project). Psychol Med 1996; 26: 143–9.CrossRefGoogle Scholar
Vitiello, B, Hill, JL, Molchan, SE, Martínez, RA, Martinson, HJ, Sunderland, T. Lack of seasonal variation in the births of patients with dementia of the Alzheimer type. Psychiatry Res 1991; 39: 21–4.CrossRefGoogle ScholarPubMed
World, Health Organisation. Composite International Diagnostic Interview. Geneva: World Health Organisation, División of Mental Health; 1990.Google Scholar
Zaudig, M, Mittelhammer, J, Hiller, W, Pauls, A, Thora, C, Morinigo, A, et al. SIDAM — a structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct dementia and dementias of other aetiology according to ICD-10 and DSM-11l-R. Psychol Med 1991; 21: 225–36.CrossRefGoogle Scholar