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Adición de sulpirida a la clozapina en pacientes esquizofrénicos resistentes al tratamiento: un estudio preliminar de una serie clínica

Published online by Cambridge University Press:  12 May 2020

R. Shiloh ,
Z. Zemishlany ,
D. Aizenberg  and
A. Weizman
R. Shiloh
Affiliation:
Hospital Psiquiátrico Geha, Petah Tikva y Facultad Sackler de Medicina, Centro de Investigación Médica Felsenstein, Universidad de Tel Aviv, Tel Aviv, Israel
Z. Zemishlany
Affiliation:
Hospital Psiquiátrico Geha, Petah Tikva y Facultad Sackler de Medicina, Centro de Investigación Médica Felsenstein, Universidad de Tel Aviv, Tel Aviv, Israel
D. Aizenberg
Affiliation:
Hospital Psiquiátrico Geha, Petah Tikva y Facultad Sackler de Medicina, Centro de Investigación Médica Felsenstein, Universidad de Tel Aviv, Tel Aviv, Israel
A. Weizman
Affiliation:
Hospital Psiquiátrico Geha, Petah Tikva y Facultad Sackler de Medicina, Centro de Investigación Médica Felsenstein, Universidad de Tel Aviv, Tel Aviv, Israel
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Resumen

Seis pacientes esquizofrénicos crónicos resistentes a los neurolépticos, que respondían parcialmente a la clozapina, recibieron conjuntamente de manera abierta durante 10 semanas 600 mg/día de sulpirida (un antagonista dopaminérgico selectivo del D 2) com o aumento al tratamiento con clozapina (un bloqueador relativamente débil del D 2). Se observó una notable reducción en los síntomas positivos y negativos en cuatro de los seis pacientes.

Keywords

esquizofreniaclozapinasulpiridadopaminaprolactina
Type
Informe clínico
Information
European Psychiatry (Ed. Española) , Volume 4 , Issue 7 , October 1997 , pp. 476 - 479
Copyright
Copyright © European Psychiatric Association 1997

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References

Bibliografia

Andreasen, NC. Scale or the Assessment of Negative Symptoms (SANS). Iowa City: The University of Iowa, 1983.Google Scholar
Andreasen, NC. Scale for the Assessment of Positive Symptoms (SANS). Iowa City: The University of Iowa, 1984.Google Scholar
Casey, DE, Gerlach, J. Sulpiride in tardive diskinesia. Psychopharmacology (Berlin) 1979; 66: 73–7.CrossRefGoogle Scholar
Cassano, GB, Castrogiovanni, P, Conti, L. Sulpiride versus haloperidol in schizophrenia: a double-blind comparative trial. Curr Ther Res 1975; 17: 189–201.Google ScholarPubMed
Edwards, JG, Alexander, JR, Alexander, MS, Gordon, A, Zutchi, T. Controlled trial of sulpiride in chronic schizophrenic patients. Br J Psychiatry 1980; 137: 522–9.CrossRefGoogle ScholarPubMed
Farmer, AE, Blewett, A. Drug Treatment of resistant schizophrenia. Drugs 1993; 45: 374–83.CrossRefGoogle ScholarPubMed
Gudelsky, GA, Nash, JF, Berry, SA. Basic biology of clozapine. Electrophysiological and neuroendocrinological studies. Psychopharmacology (Berlin) 1989; 99: 513–7.CrossRefGoogle ScholarPubMed
Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56–62.CrossRefGoogle ScholarPubMed
Hamryd, C, Bjerkenstedt, L, Bjork, K, Gullbers, B, Oxentiema, G, Sedvall, G, Wiesel, FA, Wick, G, Aberg-Wistedt, A. Clinical evaluation of sulpiride in schizoprenic patients - A double-blind comparison with chlorpromazine. Acta Psychiatr Scand 1984; 69 (suppl 311): 730.Google Scholar
Kane, J. Clinical efficacy of clozapine in treatment of refractory schizophrenia: and overview. Br J Psychiatry 1992; 18 (suppl 17): 41–5.CrossRefGoogle Scholar
Kane, J, Honigfeld, G, Singer, J, Meltzer, H. Clozapine for the treatment of resistant schizophrenia. Arch Gen Psychiatry 1988; 45: 789–96.CrossRefGoogle Scholar
Lieberman, J, Saltz, B, Johns, C, Pollak, S, Borentein, M, Kane, J. The effects of clozapine on tardive dyskinesia. Br J Psychiatry 1991; 158: 503.CrossRefGoogle ScholarPubMed
Mielke, DH, Gallant, DM, Roniger, JJ, Kessler, C, Kessler, LR. Sulpiride: evaluation of antipsychotic activity in schizophrenic patients. J Nerv Ment Dis 1977; 38: 569–71.Google ScholarPubMed
Moriuchi, K, Imazu, Y, Yoneda, H. Differences in effects of sultopride and sulpiride on dopamine tumover in rat brain. Neurochem Res 1995; 20: 95–9.CrossRefGoogle Scholar
Nishiura, M. Clinico-pharmacological studies of sulpiride. Curr Ther Res 1976; 20: 164–72.Google ScholarPubMed
Niskanen, P, Tamminen, T, Viukari, M. Sulpiride versus amitryptiline in the treatment of depression. Curr Ther Res 1975; 17: 281.Google Scholar
Overall, JE, Gorham, DE. The brief psychiatric rating scale. Psychol Rep 1961; 10: 799–812.CrossRefGoogle Scholar
Pickar, D, Owen, RR, Litman, RE, Hisiao, JK, Su, TP. Predictors of clozapine response in schizophrenia. J Clin Psychiatry 1994; 55: 129–32.Google Scholar
Pucak, ML, Grace, AA. Evidence that systematically administered dopamine antagonists active dopamine neuron firing primarily by blockade of somatodendritic autoreceptors. J Pharmacol Exp Ther 1994; 271: 1181–92.Google Scholar
Tamminga, CA, Gerlach, J. New neuroleptics and experimental anti psychotics in schizophrenia.In: Meltzer, HY, ed. Psychopharmacology, the Third Generation of Progress. New York: Raven Press, 1987: 1130–2Google Scholar