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Desarrollo de claves asociadas al alcohol y activación cerebral inducida por claves en alcohólicos

Published online by Cambridge University Press:  12 May 2020

J. Wrase
Affiliation:
Departamento de Psiquiatría de la Caridad, Universidad Humboldt de Berlín, Schumanstr. 20/21, 10117Berlín, Alemania
S. M. Grüsser
Affiliation:
Departamento de Psicología, Unidad de Psicología Clínica y Neurociencia del Comportamiento, Universidad Humboldt de Berlín, Alemania
S. Klein
Affiliation:
Departamento de Comportamiento Adictivo y Medicina de la Adicción, Instituto Central de Salud Mental, Mannheim, Alemania Departamento de NMR-Investigación, Instituto Central de Salud Mental, Mannheim, Alemania
C. Diener
Affiliation:
Departamento de Comportamiento Adictivo y Medicina de la Adicción, Instituto Central de Salud Mental, Mannheim, Alemania
D. Hermann
Affiliation:
Departamento de Comportamiento Adictivo y Medicina de la Adicción, Instituto Central de Salud Mental, Mannheim, Alemania
H. Flor
Affiliation:
Departamento de Neuropsicología, Instituto Central de Salud Mental, Mannheim, Alemania
K. Mann
Affiliation:
Departamento de Comportamiento Adictivo y Medicina de la Adicción, Instituto Central de Salud Mental, Mannheim, Alemania
D. F. Braus
Affiliation:
Departamento de NMR-Investigación, Instituto Central de Salud Mental, Mannheim, Alemania
A. Heinz
Affiliation:
Departamento de Psiquiatría de la Caridad, Universidad Humboldt de Berlín, Schumanstr. 20/21, 10117Berlín, Alemania
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Resumen

Introducción:

El objetivo de este estudio era desarrollar nuevas claves estandarizadas asociadas al alcohol y evaluar sus efectos sobre la activación cerebral con resonancia magnética nuclear funcional (RMNf). Se presentaron imágenes de bebidas alcohólicas y neutrales e imágenes neutrales afectivamente a 44 alcohólicos abstinentes y 37 sujetos de control sanos emparejados por la edad. Evaluamos la respuesta de conductancia de la piel, y la activación y la valencia provocadas. Los alcohólicos y los sujetos de control no difirieron en la activación, la valencia o la respuesta de conductancia de la piel evocadas por los estímulos asociados con el alcohol y los neutrales afectivamente, mientras que los alcohólicos evaluaron las bebidas no alcohólicas como más desagradables y activadoras, comparado con los sujetos de control. En el estudio piloto de RMNf, se presentaron imágenes relacionadas con el alcohol y abstractas a seis alcohólicos abstinentes, e indujeron una activación significativa de las áreas cerebrales asociadas con los procesos emocionales visuales, como el giro fusiforme, partes del sistema de recompensa del cerebro (ganglios basales y giro orbitofrontal) y otras regiones cerebrales en las cortezas frontal y parietal asociadas con la red de atención. Estas observaciones indican que se pueden utilizar imágenes estandarizadas de bebidas alcohólicas para evaluar los circuitos cerebrales implicados en el procesamiento y la evaluación de las claves de alcohol.

Type
Comunicación Breve
Copyright
Copyright © European Psychiatric Association 2003

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