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Scheduled prophylactic ondansetron administration did not improve its antiemetic efficacy after intracranial tumour resection surgery in children

Published online by Cambridge University Press:  01 July 2007

K. Subramaniam ,
M. P. Pandia ,
M. Dash ,
H. H. Dash ,
P. K. Bithal ,
A. Bhatia  and
B. Subramaniam
K. Subramaniam*
Affiliation:
University of Pittsburgh Medical Center, Department of Anaesthesiology, Pittsburgh, PA, USA
M. P. Pandia
Affiliation:
All India Institute of Medical Sciences, Neurosciences Center, Department of Anaesthesiology, New Delhi, India
M. Dash
Affiliation:
All India Institute of Medical Sciences, Neurosciences Center, Department of Anaesthesiology, New Delhi, India
H. H. Dash
Affiliation:
All India Institute of Medical Sciences, Neurosciences Center, Department of Anaesthesiology, New Delhi, India
P. K. Bithal
Affiliation:
All India Institute of Medical Sciences, Neurosciences Center, Department of Anaesthesiology, New Delhi, India
A. Bhatia
Affiliation:
All India Institute of Medical Sciences, Neurosciences Center, Department of Anaesthesiology, New Delhi, India
B. Subramaniam
Affiliation:
Harvard Medical School, Beth Israel Deaconess Medical Center, Department of Anaesthesiology, Boston, MA, USA
*
Correspondence to: Kathirvel Subramaniam, Department of Anaesthesiology, UPMC Presbyterian Hospital, C-Wing, 200 Lothrop Street, Pittsburgh, PA 15217, US. E-mail: subramaniamk@upmc.edu; Tel: +1 4124220575; Fax: +1 412 647 6290
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Summary

Background and objective

Postoperative nausea and vomiting after craniotomy may increase intracranial pressure and morbidity in children. This prospective, randomized, placebo-controlled and double-blinded study was designed to evaluate the antiemetic efficacy of prophylactic ondansetron after intracranial tumour resections in children.

Methods

Ninety children were divided into three groups and received saline (Group 1), ondansetron 150 μg kg−1 intravenously at dural closure (Group 2) or two doses of ondansetron 150 μg kg−1 intravenously, the second dose repeated after 6 h (Group 3). Episodes of nausea, emesis and side-effects were noted for 24 h postoperatively.

Results

Overall 24 h incidence of postoperative nausea and vomiting was not significantly different among the three groups (9 (37.5%) in Group 1 vs. 7 (27%) in Group 2 and 8 (32%) in Group 3, P = 0.73). No difference in rescue antiemetic treatment or postoperative nausea and vomiting at specific time intervals (0–6 and 6–24 h postoperative period) was seen among the three groups. No significant side-effects were noted in any of the three groups.

Conclusions

Ondansetron, in this study of 90 children, was not very effective in preventing nausea and vomiting after neurosurgical operations.

Keywords

ANAESTHESIA, neurosurgicalSURGERY, paediatric craniotomyCOMPLICATION, postoperative nausea and vomitingANTIEMETIC, ondansetron
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 24 , Issue 7 , July 2007 , pp. 615 - 619
Copyright
Copyright © European Society of Anaesthesiology 2007

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