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Genetic variability of induction and emergence times for inhalational anaesthetics

Published online by Cambridge University Press:  01 February 2008

S. Meier ,
H. Groeben ,
W. Mitzner  and
R. H. Brown
S. Meier*
Affiliation:
Universitätsklinikum Essen, Klinik für Anästhesiologie und Intensivmedizin, Essen, Germany
H. Groeben
Affiliation:
Klinik für Anästhesiologie, Intensiv und Schmerztherapie, Kliniken Essen-Mitte, Essen, Germany
W. Mitzner
Affiliation:
Johns Hopkins Bloomberg School of Public Health, EHS, Division of Physiology, Baltimore, MD, USA
R. H. Brown
Affiliation:
Johns Hopkins Bloomberg School of Public Health, EHS, Division of Physiology, Baltimore, MD, USA Johns Hopkins School of Medicine, Department of Anesthesiology and Critical Care Medicine, Baltimore, MD, USA
*
Correspondence to: Sascha Meier, Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany. E-mail: sascha.meier@uk-essen.de; Tel: +49 201 723 1401; Fax: +49 201 723 5949
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Summary

Background and objectives

Anaesthetic requirements differ among inbred mouse strains. We tested the genetic influence on induction and arousal times to inhalational anaesthetics in two of these strains.

Methods

Five male C57BL/6J (B6) and five male C3H/HeJ (C3) mice were each exposed to five different concentrations of nitrous oxide (N2O) at five different levels of halothane. Time to sleep and arousal were assessed. Data were analysed by repeated measures of analysis of variance.

Results

Halothane, N2O and genetic strain, all were significant independent factors on the time to sleep, while only N2O was a significant independent factor on the time to arousal (P = 0.004). B6 mice took significantly longer to fall asleep compared to the C3 mice controlling for halothane and N2O concentrations (F-ratio = 36, P < 0.0001). The effect of N2O on time to arousal was only significant for the B6 strain (F-ratio = 10, P = 0.005), and not for the C3 strain (F-ratio = 0.8, P = 0.38).

Conclusions

Genetics influences the time to sleep for anaesthetic agents in mice.

Keywords

INHALATIONAL ANAESTHETICS, halothane, nitrous oxideVARIATION (GENETIC)MICEINBRED STRAINSANAESTHESIA, induction time, recovery time
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 25 , Issue 2 , February 2008 , pp. 113 - 117
Copyright
Copyright © European Society of Anaesthesiology 2007

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Footnotes

Financial Support: Departmental funding.

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