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Cardiopulmonary bypass induces significant platelet activation in children undergoing open-heart surgery

Published online by Cambridge University Press:  28 January 2005

J. Guay ,
P. Ruest  and
L. Lortie
J. Guay
Affiliation:
University of Montreal, Maisonneuve-Rosemont Hospital, Department of Anesthesia, Montreal, Canada
P. Ruest
Affiliation:
University of Montreal, Ste-Justine Hospital, Department of Anesthesia, Montreal, Canada
L. Lortie
Affiliation:
University of Montreal, Ste-Justine Hospital, Department of Anesthesia, Montreal, Canada
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Extract

Summary

Background and objectives: To evaluate the effects of cardiopulmonary bypass (CPB) on platelet function in children undergoing open-heart surgery.

Methods: Data from 16 consecutive children undergoing cardiac surgery with CPB were prospectively collected. Blood samples of 10 mL were collected via the central venous line immediately before and after CPB for CD62 measurements by flow cytometry.

Results: Ten children had acyanotic heart disease (median age 3 yr, range 1.8–14) and six had a cyanotic defect (median age 4 yr, range 2–14). The platelet count decreased significantly with CPB in both groups: from 163.5 (130–201) to 93.5 (57–186) × 103 μL−1 in acyanotic children and from 139.5 (77–212) to 75 (43–99) × 103 μL−1 in cyanotic children (P < 0.0001). The percentage of activated platelets was significantly lower in acyanotic children at baseline: 1% (0–23%) vs. 5% (3–8%) (P = 0.07). CPB increased the percentage of activated platelets significantly in both groups: post-bypass the values were 10% (range 1–17%) in acyanotic children and 7% (range 1–30%) in cyanotic children (P = 0.03). The increase in the percentage of activated platelets did not differ between the two study groups (P = 0.11).

Conclusion: CPB induces significant platelet activation in children undergoing open-heart surgery.

Keywords

BLOOD LOSS, surgicalPLATELET ACTIVATIONP-SELECTIN, CD62FLOW CYTOMETRYHEART DEFECT, congenitalCARDIAC SURGICAL PROCEDURECARDIOPULMONARY BYPASS
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 21 , Issue 12 , December 2004 , pp. 953 - 956
Copyright
© 2004 European Society of Anaesthesiology

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