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Relation between bitter taste sensitivity and incidence or intensity of propofol injection pain

Published online by Cambridge University Press:  01 June 2007

V. Erden ,
G. Basaranoglu ,
Y. Korkut ,
H. Delatioglu ,
Z. Yangin  and
S. Kiroglu
V. Erden
Affiliation:
Vakif Gureba Hospital, Department of Anesthesiology, Istanbul, Turkey
G. Basaranoglu*
Affiliation:
Vakif Gureba Hospital, Department of Anesthesiology, Istanbul, Turkey
Y. Korkut
Affiliation:
Vakif Gureba Hospital, Department of ENT, Istanbul, Turkey
H. Delatioglu
Affiliation:
Vakif Gureba Hospital, Department of Anesthesiology, Istanbul, Turkey
Z. Yangin
Affiliation:
Vakif Gureba Hospital, Department of Anesthesiology, Istanbul, Turkey
S. Kiroglu
Affiliation:
Vakif Gureba Hospital, Department of Anesthesiology, Istanbul, Turkey
*
Correspondence to: Gökcen Basaranoglu, Soganlı Mah. Alper Sok. Yuvam Apartment No. 1/20, Bahcelievler, Istanbul 34590, Turkey. E-mail: gbasaranoglu@hotmail.com; Tel: +90 212 554 0570; Fax: +90 212 621 7580
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Summary

Background and objective

In human beings, pain and taste perception are two major sensory inputs. We investigated whether increasing bitter taste sensitivity would increase intensity or incidence of pain associated with propofol, and whether there is a relationship between bitter sensitivity and venepuncture pain.

Methods

One hundred (50 males, 50 females) American Society of Anesthesiologists Grade I adults undergoing elective surgery were included in this study. Determination of the taste thresholds employed a series of propylthiouracil solutions. The filter paper disk method was used to measure the taste threshold. A 20-G intravenous (i.v.) cannula was inserted in the dorsum of the non-dominant hand. Venepuncture pain was assessed by using a numerical rating scale (NRS; 0, no pain and 10, extreme pain). Propofol 10 mL (100 mg) was injected over 30 s. Assessment of pain with i.v. propofol was made using a 4-point scale: 0, no pain; 1, mild pain; 2, moderate pain; 3, severe pain.

Results

The NRS score of venepuncture pain was 2.8 ± 1.5. Sixty patients had pain during propofol injection. There was statistically significant correlation between bitter sensitivity and propofol injection pain, and between bitter sensitivity and venepuncture pain (P < 0.05).

Conclusions

We conclude that increased bitter taste sensitivity correlates with increased intensity or incidence of propofol injection pain and NRS of venepuncture pain.

Keywords

PAINPAIN MEASUREMENTPHLEBOTOMYPROPOFOLTASTE, bitter
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 24 , Issue 6 , June 2007 , pp. 516 - 520
Copyright
Copyright © European Society of Anaesthesiology 2006

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