Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-13T07:03:51.902Z Has data issue: false hasContentIssue false

Is there a neurobiological basis of insight in schizophrenia?

Published online by Cambridge University Press:  18 May 2011

Marcella Bellani*
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona (Italy) Inter-University Center for Behavioural Neurosciences (ICBN), University of Verona and University of Udine
Paolo Brambilla
Affiliation:
Section of Psychiatry, Department of Pathology and Experimental & Clinical Medicine, University of Udine, Udine (Italy) Inter-University Center for Behavioural Neurosciences (ICBN), University of Verona and University of Udine
*
Address for correspondence: Dr. M. Bellani, Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona (Italy). Fax: +39-045-585.871 E-mail: marcella.bellani@univr.it

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Neurobiology of Psychosis. Clinical and Psychosocial Implications
Copyright
Copyright © Cambridge University Press 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Aleman, A., Agrawal, N., Morgan, K.D. & David, A.S. (2006). Insight in psychosis and neuropsychological function. British Journal of Psychiatry 189, 204212.CrossRefGoogle ScholarPubMed
Amador, X.F., Strauss, D.H., Yale, S.A., Flaum, M., Endicott, J. & Gorman, J.M. (1993). Assessment of insight in psychosis. American Journal of Psychiatry 150, 873879.Google ScholarPubMed
Damasio, A.R. (1996). The somatic marker hypothesis and the possible functions of the prefrontal cortex. Philosophical Transactions of the Royal Society of London. SeriesB, Biological Sciences 351,14131420.Google Scholar
David, A. (1990). Insight and psychosis. British Journal of Psychiatry 156,798808.CrossRefGoogle ScholarPubMed
Drake, R.J., Dunn, G., Tarrier, N., Bentall, R.P., Haddock, G. & Lewis, S.W. (2007). Insight as a predictor of the outcome of first-episode nonaffective psychosis in a prospective cohort study in England. Journal of Clinical Psychiatry 68, 8186.Google Scholar
Flashman, L.A., McAllister, T.W., Andreasen, N.C. & Saykin, A.J. (2000). Smaller brain size associated with unawareness of illness in patients with schizophrenia. American Journal of Psychiatry 157,11671169.Google Scholar
Flashman, L.A., McAllister, T.W., Johnson, S.C., Rick, J.H., Green, R.L. & Saykin, A.J. (2001). Specific frontal lobe subregions correlated with unawareness of illness in schizophrenia: a preliminary study. Journal of Neuropsychiatry and Clinical Neuroscience 13, 255257.CrossRefGoogle ScholarPubMed
Keshavan, M.S., Rabinovitz, J., DeSmedt, G., Phillip, D., Harvey, D. & Schooler, N. (2004). Correlates of insight in first episode psychosis. Schizophrenia Research 70, 187194.CrossRefGoogle ScholarPubMed
Jaspers, K. (1964). Psicopatologia Generate. II Pensiero Scientifico: Roma, p. 419.Google Scholar
Lewis, A (1934). The psychopathology of insight. British Journal of Medical Psychology 14, 332348.Google Scholar
Larøi, F., Fannemel, M., Rønneberg, U., Flekkøy, K., Opjordmoen, S., Dullerud, R. & Haakonsen, M. (2000). Unawareness of illness in chronic schizophrenia and its relationship to structural brain measures and neuropsychological tests. Psychiatry Research: Neuroimaging 100, 4958.CrossRefGoogle ScholarPubMed
Nosé, M., Barbui, C. & Tansella, M. (2003). How often do patients with psychosis fail to adhere to treatment programmes? A systematic review. Psychological Medicine 33, 11491160.Google Scholar
Rossel, S.L., Coakes, J., Shapleske, J., Woodruff, W.R. & David, A. (2003). Insight: its relationship with cognitive function, brain volume and symptoms in schizophrenia Psychological Medicine 33, 111119.CrossRefGoogle Scholar
Sapara, A., Cooke, M., Fannon, D., Francis, A., Buchanan, R.W., Anilkumar, A.P.P., Arkataki, I., Aasen, I., Kuipers, E. & Kumari, V. (2007). Prefrontal cortex and insight in schizophrenia: A volumetric MRI study. Schizophrenia Research 89, 2234.CrossRefGoogle ScholarPubMed
Sartorius, N., Shapiro, R., Kimura, M. & Barrett, K. (1972). WHO International Pilot Study of Schizophrenia. Psychological Medicine 2, 422425.CrossRefGoogle ScholarPubMed
Shad, M., Muddasani, S., Prasad, K., Sweeny, J.A. & Keshavan, S.M. (2004). Insight and prefrontal cortex in first-episode schizophrenia. Neuroimage 22, 13151320.CrossRefGoogle ScholarPubMed
Shad, M., Muddasani, S. & Keshavan, M.S. (2006). Prefrontal subregions and dimensions of insight in first-episode schizophrenia-A pilot study. Psychiatry Research: Neuroimaging 146, 3542.Google Scholar
Shad, M.U., Keshavan, M.S., Tamminga, C.A., Cullum, C.M. & David, A. (2007). Neurobiological underpinnings of insight deficits in schizophrenia. International Review of Psychiatry 19, 437446.CrossRefGoogle ScholarPubMed
Young, D.A., Davila, R. & Scher, H. (1993). Unawareness of illness and neuropsychological performance in chronic schizophrenia. Schizophrenia Research 10, 117124.Google Scholar