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What is the true nature of epidemic influenza virus and how do new epidemic viruses spread?

Published online by Cambridge University Press:  19 October 2009

J. S. Oxford
J. S. Oxford
Affiliation:
National Institute for Biological Standards and Control, Holly Hill, Hampstead, London NW3.
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It might seem very late to suggest, nearly 400 years after the first clinical description of influenza and 54 years after its isolation (reviewed by Stuart-Harris. Schild & Oxford, 1985), that many fundamental questions remain to be answered about the virus itself. However the precise antigenic and biochemical structure of the natural field virus has not been established. If so much remains to be learned concerning the nature of the virion then perhaps it may be less surprising that there are some conflicting theories as regards influenza epidemiology. Such questions are raised in the current volume of the journal where Hope-Simpson & Golubev (pp. 5 54) propose a major role for virus persistence in the human disease and, a lesser role for a linked chain of acute infection spreading influenza around the world (see also Hope-Simpson. 1979: 1981). This would be a minority view of the epidemiology of influenza A at present and is most definitely in conflict with the orthodox idea of person to person spread in an endless chain.

Type
Special Article
Information
Epidemiology & Infection , Volume 99 , Issue 1 , August 1987 , pp. 1 - 3
Copyright
Copyright © Cambridge University Press 1987

References

REFERENCES

Andrewes, C. (1984). Influenza A in ferrets, mire and pigs. In The Molecular Virology and Epidemiology of Influenza (ed. Stuart-Harris, C. H. and Potter, C. W.), pp. 1London, Academie Press.Google Scholar
Burnet, F. M. & Bull, D. R. (1944) Changes in influenza virus associated with adaptation to passage in chick embryos. Australian Journal of Experimental Biology 22. 33–69.Google Scholar
Frielle, W.Huang, D. & Youngner, S. (1984). Persistent infection with influenza A virus: evolution of virus mutants. Virology 138. 103–117.CrossRefGoogle ScholarPubMed
Holland, J., Spindler, K., Horodyski, F., Grabae, K.. Nichol, S. (1982). Rapid evolution of RNA genomes. Science 215. 1577–1785.CrossRefGoogle ScholarPubMed
Hope-Simpson, R. E. (1954). Studies on shingles: is the virus ordinary chicken pox Lancet. 1299–1302.Google Scholar
Hope-Simpson, R. E. (1979). Epidemie mechanisms of type A influenza. Journal of Hygiene, 83. 11–26.CrossRefGoogle Scholar
Hope-Simpson, R. E. (1981) The role of season in the epidemiology of influenza. Journal of Hugiene 86, 35–47.Google ScholarPubMed
Jacobs, J. P. (1970) Some comparative characterises of WI-38 and MRC5 cells and their suitability for the production of viral vaccines. In Proceedings of the Symposium on Human Diploid Cells, pp. 43 55, Zagreb: Yugoslav Academy ot Science.Google Scholar
Oxford, J. S., Corcoran, T., Knott, R., Bates, J., Bartolomel, O., Major, D., Newman, R. W., Robertson, J., Webster, R. G. & Schild, G. C., (1987) Serolgieal studies of inhuenza A (HINI) viruses eultivated in eggs or in a eanine kidney cell line (MDCK). Bulletin of World Health Organisation (In the Press)Google Scholar
Robertson, J. S., Naeve, C. W., Webster, R. G., Bootman, J. S., Newman, R. & Schild, G. C., (1985). Alterations in the haemagglutinin associated with adaptation of intluenza B virus to growth in eggs. Virology, 143, 166–174.CrossRefGoogle ScholarPubMed
Schild, G. C., Oxford, J. S., de Yong, J. C. & Webster, R. G., (1983) Evidence for host cell selection of influenza virus antigenic variants, Nature, 303. 706–709.CrossRefGoogle ScholarPubMed
Stuart-Harris, C. H., Schild, G. C. & Oxford, J. S. (1985). Influenza The Viruses and the Disease. PP.264. London. Edward Arnold.Google Scholar
Yewdell, J. W., Webster, R. G. & Gerhard, W. U. (1979). Antigenic variation in three distinct determinants of an influenza type A haemagglutinin molecule. Nature 279, 246–248.CrossRefGoogle ScholarPubMed