Hostname: page-component-6d856f89d9-vrt8f Total loading time: 0 Render date: 2024-07-16T06:01:38.565Z Has data issue: false hasContentIssue false
  • English
  • Français

The survival of the Calmette-Guérin strain of tubercle bacillus (B.C.G.) in the blood and mamma of goats

Published online by Cambridge University Press:  15 May 2009

A. Stanley Griffith
A. Stanley Griffith
Affiliation:
From the Field Laboratories, Cambridge
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Intravenously injected into a goat in a single dose of 50·0 mg. b.c.g. caused the death of the animal from pneumonia in 9 days and was demonstrated in the blood until the day of death, though in progressively diminishing numbers.

Intravenously injected into a goat on successive occasions, the dose on each being 10·0 mg., b.c.g. was filtered from the blood by the tissues within 3–5 days. There was little or no evidence that b.c.g. disappeared from the blood more quickly after previous injection of that micro-organism. b.c.g. was not excreted into the milk cisterns of this goat or, if excreted, the bacilli did not long survive.

Intramammarily injected b.c.g. produced inflammatory reactions in the mamma with formation of caseo-pus and ultimate destruction of the gland as a secretory organ. The micro-organisms, however, did not remain alive for any lengthy period in the mamma and in the two instances reported were not viable after about 15 weeks.

Type
Research Article
Information
Journal of Hygiene , Volume 41 , Issue 3 , November 1941 , pp. 266 - 271
Copyright
Copyright © Cambridge University Press 1941

References

REFERENCES

Cobbett, L. (1917). The Causes of Tuberculosis. Cambridge.Google Scholar
Griffith, A. S. (1911). The excretion of tubercle bacilli in the milk of animals. Roy. Comm. Tuberc. Final Report, App. 3, p. 79.Google Scholar
Griffith, A. S. (1913). Human tubercle bacilli in the milk of a vaccinated cow. J. Path. Bact. 17, 323.CrossRefGoogle Scholar
Griffith, A. S. (1917). An investigation of strains of tubercle bacilli from animal tuberculosis. J. Path. Bact. 21, 329.CrossRefGoogle Scholar
Griffith, A. S. (1935). Tuberculous Bacillaemia. Quart. Bull. Hlth Org. L.o.N. 4, 283. Reprinted in Acta Tuberculosea Scandinavica. 9, 229.Google Scholar
Griffith, A. S. (1938). Avian tubercle bacilli in the udder of a goat—change of S to R forms. J. comp. Path. Therap. 51, 151.CrossRefGoogle Scholar