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Study of an attenuated strain of feline infectious enteritis (panleucopaenia) virus I. Spread of vaccine virus from cats affected with feline respiratory disease

Published online by Cambridge University Press:  15 May 2009

K. J. O'Reilly
K. J. O'Reilly
Affiliation:
Wellcome Research Laboratories, Langley Court, Beckenham, Kent
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Summary

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In the course of developing a living attenuated feline infectious enteritis (panleucopaenia) vaccine, it was found that respiratory disease-infected cats newly inoculated with this vaccine spread vaccine virus to respiratory disease-infected in-contact controls. These in-contact controls were able to infect other cats with which they were placed in contact so that after five natural transmissions in this way and two oral administrations and subsequent re-isolations, reversion to virulence became evident. It is clear that before general release of a new living feline infectious enteritis vaccine, there must be satisfactory evidence that con-current infection will not affect the safety of the modified antigen.

In cats infected with feline infectious enteritis there appears to be a short period, coinciding with the onset of leucopaenia, during which they are highly infectious. It seems possible that some infected animals may become immune carriers because virus has been recovered from the small intestine of two of four cats with significant antibody titres 22–24 days after exposure to infection.

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 4 , December 1971 , pp. 627 - 635
Copyright
Copyright © Cambridge University Press 1971

References

REFERENCES

Bouillant, A. & Hanson, R. P. (1965). Epizootiology of mink enteritis. III. Carrier state in mink. Canadian Journal of Comparative Medicine 29, 183.Google Scholar
Hammon, W. D. & Enders, J. F. (1939). A virus disease of cats, principally characterized by aleucocytosis, enteric lesions, and the presence of intranuclear inclusion bodies. Journal of Experimental Medicine 69, 327.CrossRefGoogle ScholarPubMed
Lawrence, J. S. & Syverton, J. T. (1938). Spontaneous agranulocytosis in the cat. Proceedings of the Society for Experimental Biology and Medicine 39, 914.CrossRefGoogle Scholar
O'Reilly, K. J. (1970). Determination of an optimal dilution of virulent feline infectious enteritis (panleucopaenia) virus for challenge purposes. Journal of Hygiene 68, 549.Google Scholar
O'Reilly, K. J., Paterson, J. S. & Harriss, S. T. (1969). The persistence in kittens of maternal antibody to feline infectious enteritis (panleucopaenia). Veterinary Record 84, 376.CrossRefGoogle Scholar
O'Reilly, K. J. & Whitaker, A. M. (1969). The development of feline cell lines for the growth of feline infectious enteritis (panleucopaenia) virus. Journal of Hygiene 67, 115.CrossRefGoogle ScholarPubMed