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Rubella in Orkney: seroepidemiology and vaccination

Published online by Cambridge University Press:  15 May 2009

Margaret A. J. Moffat ,
S. N. Heywood ,
Eileen Laughton ,
Janine J. Gould  and
D. S. Freestone
Margaret A. J. Moffat
Affiliation:
Department of Bacteriology, Foresterhill, Aberdeen
S. N. Heywood
Affiliation:
Health Centre, Kirkwall, Orkney
Eileen Laughton
Affiliation:
Health Centre, Kirkwall, Orkney
Janine J. Gould
Affiliation:
The Wellcome Research Laboratories, Beckenham, Kent
D. S. Freestone
Affiliation:
The Wellcome Research Laboratories, Beckenham, Kent
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Summary

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Rubella haemagglutination inhibiting (HAI) antibody titres were determined in 54 seronegative women and 31 naturally immune women after vaccination and revaccination with Wistar RA27/3 strain rubella vaccine administered by the intranasal or subcutaneous routes or revaccination with the Cendehill strain administered subcutaneously. In addition, HAI antibody titres were determined in 46 seronegative schoolgirls after vaccination with the Cendehill strain and revaccination with the RA27/3 strain.

All seronegative women vaccinated with the RA27/3 strain developed antibody, peak titres being reached 6 weeks after vaccination. Six months after vaccination with the Cendehill strain, 45 (98%) of the 46 seronegative girls had developed antibody, but 11 (24%) had not reached their peak titre by 6 weeks, suggesting a slower response than that elicited by the RA27/3 strain. Revaccination did not induce significant antibody responses in the seronegative women vaccinated 6 months previously with RA27/3 but 4 naturally immune women developed an eightfold increase in antibody. In 10 (22%) of 46 schoolgirls previously vaccinated with the Cendehill strain a significant rise in antibody followed revaccination with RA27/3. These results provide further evidence of the more rapid antibody responses elicited by the RA27/3 vaccine in comparison with the Cendehill vaccine.

An outbreak of natural rubella occurred in 1972 and 97 cases were confirmed serologically. The clinical disease was more common in older school-children and in adults. More males than females were affected in the 11–15 age group, the sex ratio being 18:12; this may be explained by the routine vaccination of girls of this age group as part of the national programme which began in 1970. The significance of the persistence of high HAI antibody titres after natural infection and the effect of the epidemic on the serological status of the population are discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 78 , Issue 3 , June 1977 , pp. 419 - 427
Copyright
Copyright © Cambridge University Press 1977

References

REFERENCES

Brody, J. A., Sever, J. L., McAlister, R., Schiff, G. M. & Cutting, R. (1965). Rubella epidemic on St Paul Island in the Pribilofs, 1963. Journal of the American Medical Association 191, 83.Google Scholar
Brown, T., Hambling, M. H. & Ansari, B. M. (1969). Rubella-neutralizing and haemagglutinin-inhibiting antibodies in children of different ages. British Medical Journal iv, 263.CrossRefGoogle Scholar
Chang, T-W. (1974). Rubella reinfection and intrauterine involvement. Journal of Pediatrics 84, 617.CrossRefGoogle ScholarPubMed
Eilard, T. & Strannegård, Ö. (1974). Rubella reinfection in pregnancy followed by transmission to the foetus. Journal of Infectious Diseases 129, 594.CrossRefGoogle Scholar
Fogel, A., Moshkowitz, A., Rannon, L. & Gerichter, C. B. (1971). Comparative trials of RA27/3 and Cendehill rubella vaccines in adult and adolescent females. American Journal of Epidemiology 93, 392.CrossRefGoogle Scholar
Freestone, D. S., Reynolds, G. M., McKinnon, J. A. & Prydie, J. (1975). Vaccination of schoolgirls against rubella. British Journal of Preventive and Social Medicine 29, 258.Google ScholarPubMed
Grillner, Lena (1975). Neutralizing antibodies after rubella vaccination of newly delivered women: a comparison between three vaccines. Scandinavian Journal of Infectious Diseases 7, 169.CrossRefGoogle ScholarPubMed
Hattis, R. P., Halstead, S. B., Herrmann, K. L. & Witte, J. J. (1973). Rubella in an immunized island population. Journal of the American Medical Association 223, 1019.CrossRefGoogle Scholar
Moffat Margaret, A. J., Gould Janine, J., Forbes, F. A., Freestone, D. S. & Macdonald, A. (1972). Studies with rubella vaccine (RA27/3) using the subcutaneous and intranasal routes. Scottish Medical Journal 17, 140.CrossRefGoogle Scholar
Paul, N. R., Rhodes, A. J., Campbell, J. B. & Labzoffsky, N. A. (1974). Rubella precipitin response in natural infection and in vaccination. Archiv für die gesamte Virus-forschung 45, 335.CrossRefGoogle ScholarPubMed
Plotkin, S. A. & Farquhar, J. D. (1972). Immunity to rubella: comparison between naturally and artificially induced resistance. Postgraduate Medical Journal 48, Suppl. (3) 47.Google Scholar
Plotkin, S. A., Farquhar, J. D. & Ogra, P. L. (1973). Immunologic properties of RA27/3 rubella virus vaccine. Journal of the American Medical Association 225, 585.CrossRefGoogle ScholarPubMed
Public Health Laboratory Service (1968). Studies on rubella in pregnancy. British Medical Journal iii, 203.Google Scholar
Ross, M. G. R. (1974). A serological survey for rubella antibody. Fiji Medical Journal 2, 133.Google Scholar
Sever, J. L., Schiff, G. M., Bell, J. A., Kapikian, A. Z., Huebner, R. J. & Traub, R. G. (1965). Rubella antibody in children and adults. Pediatrics 35, 996.CrossRefGoogle ScholarPubMed
Swartz, T. A., Praiss, I., Isacson, M., Nishmi, M., Ben-Porath, Edna & Hornstein, Leah (1975). Early results of an extensive rubella epidemic. International Journal of Epidemiology 4, 331.CrossRefGoogle ScholarPubMed
Thomssen, R. (1973). Vergleich der Antikörperbildung nach parenteraler Schutzimpfung mit den Rubella-Impfstoffen ‘Cendehill’ und RA27/3. Deutsche medizinische Wochenschrift 98, 1555.CrossRefGoogle Scholar
Tobin, J. O'H. (1971). Rubella vaccination of postpartum women and of adolescents in the North West of England. Canadian Journal of Public Health 62, Suppl. 64.Google Scholar
Tómasson, H. Ó. and Ögmundsdóttir, Helga M. (1975). Rubella in Iceland. Acta pathologica et microbiologica scandinavica B 83, 275.Google Scholar