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The Results of some Quantitative Experiments on the Serum Precipitation Reaction

Published online by Cambridge University Press:  15 May 2009

G. L. Taylor
G. L. Taylor
Affiliation:
John Lucas Walker Student, Department of Pathology, University of Cambridge.
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The work described in this paper is based, very largely, on the work of Dean and Webb (1926), and the methods used in the various experiments are similar to those described by them. The results are discussed in two parts. The first is concerned with the mixture of different specimens of anti-horse serum, and with the relationship of the antibody in one specimen to the antibody in another. The second part deals with the nature of the reaction between antigen and antibody in the serum precipitation reaction. The two parts are dependent on each other, and the subject of the second suggested itself whilst the work on the first was in progress. The order in which the work is described is mostly that in which it was done. Nevertheless, conclusions arrived at in one part are, in one or two cases, of importance in the consideration of the other part, and vice versa. A question as to the possibility of strengthening the ratio of an antiserum by the addition of another antiserum led to the earlier experiments.

Type
Research Article
Information
Journal of Hygiene , Volume 31 , Issue 1 , January 1931 , pp. 56 - 83
Copyright
Copyright © Cambridge University Press 1931

References

REFERENCES

Bordet, J. (1903). Sur le mode d'action des antitoxines sur les toxines. Ann. Inst. Pasteur, 17, 161.Google Scholar
Danysz, J. (1902). Contribution à l'étude des propriétés et de la nature des mélanges des toxines avec les antitoxines. Ann. Inst. Pasteur, 16, 331.Google Scholar
Dean, H. R. (1912). On the mechanism of complement fixation. J. Hygiene, 12, 259.Google Scholar
Dean, H. R. (1916). The influence of temperature on the fixation of complement. J. Path. and Bact. 21, 193.CrossRefGoogle Scholar
Dean, H. R. and Webb, R. A. (1926). The influence of optimal proportions of antigen and antibody in the serum precipitation reaction. J. Path. and Bact. 29, 473.CrossRefGoogle Scholar
Ehrlich, P. (1900). On immunity with special reference to cell life. Proc. Roy. Soc. 66, 424.Google Scholar
Freundlich, H. (1926). Colloid and Capillary Chemistry. English translation. London.Google Scholar
Goldsworthy, N. E. (1928). The occurrence of multiple zones in the serum precipitation reaction. J. Path. and Bact. 31, 525.CrossRefGoogle Scholar
Hartley, P. (1925). Observations on the rôle of the ether soluble constituents of serum in certain serological reactions. Brit. J. Exp. Path. 6, 180.Google Scholar
Heidelberger, M. and Kendall, F. E. (1929). A quantitative study of the precipitin reaction between Type III pneumococcus polysaccharide and purified homologous antibody. J. Exp. Med. 50, 809.Google Scholar
Ramon, G. (1923). La floculation dans les mélanges de toxine et de serum antidiphtérique. Ann. Inst. Pasteur, 37, 1001.Google Scholar
Wu, H., Sah, P. P. T. and Li, C. P. (1929). Composition of antigen-precipitate. Proc. Soc. Exp. Biol. and Med. 26, 737.Google Scholar