Hostname: page-component-76fb5796d-45l2p Total loading time: 0 Render date: 2024-04-26T21:04:09.570Z Has data issue: false hasContentIssue false
  • English
  • Français

Protection from natural infection after live influenza virus immunization in an open population*

Published online by Cambridge University Press:  15 May 2009

G. Rocchi ,
L. Carlizza ,
M. Andreoni ,
G. Ragona ,
C. Piga ,
A. Pelosio ,
A. Volpi  and
A. Muzzi
G. Rocchi
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
L. Carlizza
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
M. Andreoni
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
G. Ragona
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
C. Piga
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
A. Pelosio
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
A. Volpi
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
A. Muzzi
Affiliation:
Institute of Hygiene, University of Rome
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Live attenuated influenza vaccine containing the recombinant of A/Victoria/3/75 with A/PR/8/34 virus was administered to healthy adults in a field trial aimed at evaluating protection provided by immunization. The study was designed to measure the effect of vaccination on absenteeism from respiratory disease during a natural influenza epidemic. A total of 2115 male employees of the public transport service of Rome volunteered to participate in the trial, 1050 and 1065 receiving vaccine and placebo respectively, in a randomized blind fashion. Vaccination procedure was completed by the end of December 1976. A small-sized outbreak of influenza, due to a viral strain antigenically homologous to the vaccine, occurred during the month of February 1977. Analysis of absenteeism data, classified according to medical certificate, indicated that morbidity from respiratory disease was reduced in vaccinees compared with controls during the epidemic month; the rate of increase of morbidity compared with that of the preceding month was then three times lower in vaccinees than in controls and the difference in absenteeism between the two groups greatly exceeded the ordinary fluctuation that was observed during non-epidemic periods.

Type
Research Article
Information
Journal of Hygiene , Volume 82 , Issue 2 , April 1979 , pp. 231 - 236
Copyright
Copyright © Cambridge University Press 1979

References

REFERENCES

Alexandrova, G. I., Smorodintsev, A. A., Beljaeva, N. M., Vasil'ev, B., Geft, R. A., Panteleev, V. G., Siefer, M. A. & Selivanov, A. A. (1970). Testing the safety and effectiveness of oral administration of a live influenza vaccine. Bulletin of the World Health Organization 42, 429.Google Scholar
Beare, A. S., Habershon, R. B., Tyrrell, D. A. J. & Hall, T. S. (1973). Recombinant live influenza vaccine virus; tests of transmissibility in man. Journal of Biological Standardization 1, 233.Google Scholar
Crifò, S., Filiaci, F., Pelosio, A. & Roccni, G. (1978). Risposta secretoria e sierica dopo vaccinazione antiinfluenzale per via nasale con virus vivo attenuato A/Victoria/3/75. Bollettino della Società Italiana di Biologia Sperimentale (in the Press).Google Scholar
Donikian, M. A., McKee, J. & Greene, L. C. (1977). Challenge versus natural infection as an index of protection after influenza immunization. Developments in Biological Standardization 39, 149.Google ScholarPubMed
Ikic`, D., Pasini, N., Hec`imovic`, M., Juzbašić, M., Smerdel, S., Rajner, N. & Jelavić, V. (1977). Attenuation of influenza A/New Jersey/76 virus strain, preparation of live vaccine and vaccine reactogenicity in volunteers. Developments in Biological Standardization 39, 61.Google Scholar
Kunz, C. H. & Hofmann, H. (1977). Field study with a live influenza vaccine (RIT 4050) in children. Developments in Biological Standardization 39, 93.Google Scholar
Lobmann, M., Delem, A. & Jovanovic, D. (1977). Properties of A/Victoria/3/75 recombinants: development of an attenuated strain RIT 4050. Developments in Biological Standardization 39, 43.Google ScholarPubMed
MacKenzie, J. S., MacKenzie, I., Lloyd, J. & Dent, V. (1975). Comparative trials of live attenuated and detergent split influenza virus vaccines. Journal of Hygiene 75, 425.Google Scholar
McDonald, J. C., Zuckerman, A. J., Beare, A. S. & Tyrrell, D. A. J. (1962). Trials of live influenza vaccine in the Royal Air Force. British Medical Journal i, 1036.Google Scholar
Minor, T. E., Dick, E. C., Dick, R. C. & Inhorn, S. L. (1975). Attenuated influenza A vaccine (Alice) in an adult population: Vaccine-related illness, serum and nasal antibody production and intrafamily transmission. Journal of Clinical Microbiology 2, 403.CrossRefGoogle Scholar
Munphy, B. R., Chalbub, E. G., Nusinoff, S. R. & Chanock, R. M. (1972). Temperature-sensitive mutants of influenza virus. II. Attenuation of ts recombinants for man. Journal of Infectious Diseases 126, 170.Google Scholar
Nicholson, K. G., Lawford, C. V. P. & Tyrrell, D. A. J. (1977). Studies of respiratory function in volunteers given live influenza virus vaccine. Developments in Biological Standardization 39, 129.Google Scholar
Noble, G. B., Corey, L., Rosenberg, R. L., Hoke, K., Brown, W. J., Kaye, H. S., Bregman, D. J., Gregg, M. B. & Dowdle, W. R. (1975). An open field trial of live attenuated influenza A/England/42/72 (H3N2) vaccine. II. Illness and infection rates during an epidemic of A/Port Chalmers/-like influenza. 15th Interscience Conference on Antimicrobial Agents and Chemotherapy,Washington, D.C. (abstract).Google Scholar
Petrilli, F. L., Crovari, P., Crovai-Cuneo, P., Badolati, G. & Canepa, R. (1975). Oral influenza vaccination with live attenuated viruses. I. Acceptability, immunogenicity and transmissibility. Bollettino dell'Istituto Sieroterapico Milanese 54, 312.Google Scholar
Prèvost, J. M., Peetermans, J., Lamy, F. & Huygelen, C. (1973). Immune response to vaccination with a live influenza virus (H3N2) vaccine (‘Ann’ strain). Infection and Immunity 8, 420,CrossRefGoogle ScholarPubMed
Ragona, G., Giunchi, G., Rocchi, G., Muzzi, A. & De Felici, A. (1978). Excess mortality from influenza in a large urban population, Rome, Italy, 1956–76. Journal of Hygiene 80, 249.Google Scholar
Rubin, R. G., Noble, G. R., Corey, L., Brown, W. J., Brandling-Bennett, D., Kaye, H. S., Coleman, M. T., Gregg, M. B. & Dowdle, W. R. (1976). Live, attenuated influenza A/England/42/72 (H3N2) virus vaccine: a field trial. Journal of Infectious Diseases 133, 603.Google Scholar
Rytel, M. W., Jackson, L. J., Ferstenfeld, J. E. & Rosenkranz, M. A. (1975). New live attenuated influenza A/England/42/72 (H3N2) vaccine (Alice): reactogenicity, immunogenicity, and protection efficacy. Journal of Infectious Diseases 132, 652.Google Scholar
Rytel, M. W., Jackson, L. J., Niebojewski, R. A., Haagensen, J. L. & Rosenkranz, M. A. (1977). Field trial of live attenuated influenza A/B (‘Alice’/R-75) vaccine. American Journal of Epidemiology 105, 49.CrossRefGoogle ScholarPubMed
Serfling, R. E. (1963). Methods for current statistical analysis of excess pneumonia-influenza deaths. Public Health Reports 78, 494.CrossRefGoogle Scholar
Sever, J. L. (1962). Application of a microtechnique to viral serological investigations. Journal of Immunology 88, 320.Google Scholar