Almost from the time when pellagra was first described, a connection between the disease and maize as an article of diet has been noted, and a wordy and voluminous literature has arisen in the countries afflicted concerning the nature of this suggested relationship between maize and pellagra. Most of what has hitherto been written about pellagra is based upon observations on clinical material and epidemics. Probably the most neglected side of the disease is its morbid anatomy and histology; and the effects of feeding animals on preparations of maize are but scantily described.