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A non-specific complement-fixing system in foot-and-mouth disease and experiments on the absorption of heterologous antibody from serum

Published online by Cambridge University Press:  15 May 2009

J. B. Brooksby  and
S. Erichsen
J. B. Brooksby
Affiliation:
Research Institute (Animal Virus Diseases), Pirbright, Surrey
S. Erichsen
Affiliation:
Research Institute (Animal Virus Diseases), Pirbright, Surrey
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Stored mixtures of the virus and corresponding antisera in foot-and-mouth disease have equal complement-fixing activity whether they are prepared from virus and serum of homologous or heterologous types. On ultracentrifugation the complement-fixing activity is removed from the mixture and the remaining antibody is more sharply type-specific in routine complement-fixation tests than the original serum.

Type
Research Article
Information
Journal of Hygiene , Volume 54 , Issue 3 , September 1956 , pp. 328 - 334
Copyright
Copyright © Cambridge University Press 1956

References

REFERENCES

Bradish, C. J., Brooksby, J. B., Dillon, J. F. & Norambuena, N. (1952). Ultracentrifugal studies of the infective and complement-fixing components in the virus system of foot-and-mouth disease. Proc. roy. Soc. B, 140, 107.Google Scholar
Brooksby, J. B. (1952). The technique of complement-fixation in foot-and-mouth disease research. Spec. Rep. Ser. Agric. Res. Coun., Lond., no. 12. H.M.S.O.Google Scholar
Henle, W., Henle, G., Groupi, V. & Chambers, L. A. (1944). Studies on complement-fixation with the viruses of influenza. J. Immunol. 48, 163.CrossRefGoogle Scholar