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Induction of immunological memory in UK infants by a meningococcal A/C conjugate vaccine

Published online by Cambridge University Press:  01 June 2000

R. BORROW ,
A. J. FOX ,
P. C. RICHMOND ,
S. CLARK ,
F. SADLER ,
J. FINDLOW ,
R. MORRIS ,
N. T. BEGG  and
K. A. V. CARTWRIGHT
R. BORROW
Affiliation:
Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester, M20 2LR, UK
A. J. FOX
Affiliation:
Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester, M20 2LR, UK
P. C. RICHMOND
Affiliation:
Immunisation Division, Communicable Disease Surveillance Centre, Public Health Laboratory Service, 61 Colindale Avenue, London NW9 5EQ, UK
S. CLARK
Affiliation:
Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester, M20 2LR, UK
F. SADLER
Affiliation:
Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester, M20 2LR, UK
J. FINDLOW
Affiliation:
Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester, M20 2LR, UK
R. MORRIS
Affiliation:
Public Health Laboratory, Gloucestershire Royal Hospital, Gloucester, GL1 3NN, UK
N. T. BEGG
Affiliation:
Immunisation Division, Communicable Disease Surveillance Centre, Public Health Laboratory Service, 61 Colindale Avenue, London NW9 5EQ, UK
K. A. V. CARTWRIGHT
Affiliation:
Public Health Laboratory, Gloucestershire Royal Hospital, Gloucester, GL1 3NN, UK
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Abstract

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The induction of immunological memory to serogroup A and C polysaccharides in UK infants immunized with three doses of a meningococcal A/C oligosaccharide CRM197 conjugate vaccine was investigated. Forty UK infants vaccinated previously with three doses of a meningococcal A/C oligosaccharide-CRM197 conjugate vaccine at 2, 3 and 4 months of age, were revaccinated at a mean age of 145·6 weeks with either a 10 or 50 μg dose of licensed meningococcal A/C polysaccharide vaccine. Serogroup-specific antibody and serum bactericidal antibody (SBA) responses were measured by enzyme-linked immunosorbent assay and serum bactericidal assays, respectively. Following challenge, anti-serogroup A and C polysaccharide antibody levels rose from pre-booster geometric mean concentrations (GMC) of 3·1 and 2·1 μg/ml respectively to 19·6 and 21·0 μg/ml 1 month post-booster. Serum bactericidal antibody geometric mean titres (GMTs) for serogroups A and C increased 156- and 113-fold from 2·1 and 7·1 pre-booster respectively to 327·4 and 800·7 post-booster. A serogroup A control group of 45 children received a 10 μg dose of licensed meningococcal A/C polysaccharide vaccine (with no prior history of serogroup A vaccination) had serogroup A SBA GMTs of 2·3 pre- vaccination rising to 8 post-vaccination with corresponding GMCs of 0·8 and 10·8 μg/ml. These rises in SBA following serogroup A/C conjugate vaccination are indicative of immunological priming.

Type
Research Article
Information
Epidemiology & Infection , Volume 124 , Issue 3 , June 2000 , pp. 427 - 432
Copyright
© 2000 Cambridge University Press