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Immunogenicity of boiled compared with formalized leptospiral vaccines in rabbits, hamsters and humans

Published online by Cambridge University Press:  15 May 2009

B. Adler  and
S. Faine
B. Adler
Affiliation:
Department of Microbiology, Monash University Medical School, Alfred Hospital, Commercial Road, Prahran, Victoria 3181, Australia
S. Faine
Affiliation:
Department of Microbiology, Monash University Medical School, Alfred Hospital, Commercial Road, Prahran, Victoria 3181, Australia
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Summary

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Leptospires (Leptospira interrogaus serovar pomona) grown in chemically defined medium were immunogenic when given intradermally in humans if the leptospires were killed with formalin but not if they were boiled. Boiled leptospires were immunogenic for rabbits and hamsters and protected hamsters from challenge infection. On the other hand, boiled leptospires of the biflexa complex, serovar patoc, did retain some immunogenicity in humans, but the antisera did not protect hamsters against challenge with serovar pomona.

Type
Research Article
Information
Journal of Hygiene , Volume 84 , Issue 1 , February 1980 , pp. 1 - 10
Copyright
Copyright © Cambridge University Press 1980

References

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