Hostname: page-component-76fb5796d-skm99 Total loading time: 0 Render date: 2024-04-28T07:46:21.147Z Has data issue: false hasContentIssue false
  • English
  • Français

The immunization of mice and calves with gal E mutants of Salmonella typhimurium

Published online by Cambridge University Press:  15 May 2009

C. Wray ,
W. J. Sojka ,
J. A. Morris  and
W. J. Brinley Morgan
C. Wray
Affiliation:
Central Veterinary Laboratory, Weybridge, Surrey
W. J. Sojka
Affiliation:
Central Veterinary Laboratory, Weybridge, Surrey
J. A. Morris
Affiliation:
Central Veterinary Laboratory, Weybridge, Surrey
W. J. Brinley Morgan
Affiliation:
Central Veterinary Laboratory, Weybridge, Surrey
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A galactose epimeraseless (gal E) mutant of Salmonella typhimurium was investigated in mice and calves for its suitability as a live vaccine. In mice, a very highly significant difference in the mortality rates was observed when vaccinated and non-vaccinated animals were challenged with virulent strains of S. typhimurium and S. dublin.

In calves, doses of 106 and above of gal E mutant injected subcutaneously provided highly significant protection both in terms of mortality and prevalence of symptoms when calves were challenged orally with S. typhimurium. However, there appeared to be a relation between the vaccine and the presence of renal lesions and before gal E mutants can be recommended, further work is necessary to determine the pathogenesis of these lesions.

Type
Research Article
Information
Journal of Hygiene , Volume 79 , Issue 1 , August 1977 , pp. 17 - 24
Copyright
Copyright © Cambridge University Press 1977

References

REFERENCES

Anderson, E. S. (1968). Drug resistance in Salmonella typhimurium and its implications. British Medical Journal 3, 333–9.CrossRefGoogle ScholarPubMed
Germanier, R. (1970). Immunity in experimental salmonellosis. I. Protection by rough mutants of Salmonella typhimurium. Infection & Immunity 2, 309–15.CrossRefGoogle ScholarPubMed
Germanier, R. (1972). Immunity in experimental salmonellosis. III. Comparative immunization with viable and heat inactivated cells of Salmonella typhimurium. Infection & Immunity 5, 792–7.CrossRefGoogle Scholar
Germanier, R. & Fürer, E. (1971). Immunity in experimental salmonellosis. II. Basis for the avirulence and protective capacity of gal E mutants of Salmonella typhimurium. Infection & Immunity 4, 663–73.CrossRefGoogle Scholar
Lawson, G. H. K. & Dow, C. (1964). Production of the generalized Shwartzman reaction with Salmonella cholerae-suis. Journal of Comparative Pathology 74, 482–6.CrossRefGoogle ScholarPubMed
McCoy, J. H. (1976). Salmonella infections of man derived from animals. Royal Society of Health Journal 96, 25–9.CrossRefGoogle ScholarPubMed
Morris, J. A., Wray, C. & Sojka, W. J. (1976). The effect of T and B lymphocyte depletion on the protection of mice vaccinated with a Gal E mutant of Salmonella typhimurium. British Journal of Experimental Pathology 57, 354–60.Google Scholar
Plant, Janet & Glynn, A. A. (1976). Genetics of resistance to infection with Salmonella typhimurium in mice. Journal of Infectious Diseases 133, 72–8.CrossRefGoogle ScholarPubMed
Rankin, J. D., Newman, G. & Taylor, R. J. (1966). The protection of calves against infection with Salmonella typhimurium by means of Salmonella dublin (Strain 51) vaccine. Veterinary Record 78, 765–6.Google Scholar
Robson, H. G. & Vas, S. I. (1972). Resistance of inbred mice to Salmonella typhimurium. Journal of Infectious Diseases 126, 378–86.CrossRefGoogle ScholarPubMed
Smith, H. Williams (1965). The immunization of mice, calves and pigs against Salmonella dublin and S. choleraesuis infections. Journal of Hygiene 63, 117–35.CrossRefGoogle Scholar
Smith, H., Williams& Halls, Sheila & Halls, Sheila (1966). The immunity produced by a rough Salmonella dublin variant against Salmonella typhimurium and Salmonella choleraesuis infection in guinea-pigs. Journal of Hygiene 64, 357–9.CrossRefGoogle ScholarPubMed
Sojka, W. J., Wray, C., Hudson, E. B. & Benson, J. A. (1975). Incidence of salmonella infection in animals in England and Wales, 1968–73. Veterinary Record 96, 280–9.Google Scholar