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Immunization against typhoid and paratyphoid with alcohol-killed, alcohol-preserved and heat-killed, phenol-preserved, vaccine

Published online by Cambridge University Press:  15 May 2009

Hugh Climie
Hugh Climie
Affiliation:
Deputy Medical Officer of Health, Kirkcaldy
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1. A comparison of the agglutinogenic response and reactions, both local and general, between a series of sixty-two persons immunized with alcohol-killed, alcohol-preserved, T.A.B.C. vaccine, and forty-four persons immunized with a much older heat-killed, phenol preserved, T.A.B.C. vaccine is described.

2. It was found that there was comparatively little difference between the two series in regard to O agglutinin response.

3. Vi agglutinins were found in 14·4 % of the alcohol-vaccine cases, but none appeared in the heat-killed, phenolized vaccine cases.

4. There was no significant difference in the frequency of local reactions, but the general reactions were markedly fewer in the alcohol-vaccine cases.

5. The occurrence of Vi agglutinin response in six out of fifteen cases given heatkilled, phenol-preserved, T.A.B.C. or T.A.B. vaccines intravenously is recorded.

Type
Research Article
Information
Journal of Hygiene , Volume 42 , Issue 4 , July 1942 , pp. 411 - 415
Copyright
Copyright © Cambridge University Press 1942

References

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