Hostname: page-component-848d4c4894-cjp7w Total loading time: 0 Render date: 2024-06-30T17:47:47.794Z Has data issue: false hasContentIssue false
  • English
  • Français

Epidemiology of infection due to Escherichia coli O157: a 3-year prospective study

Published online by Cambridge University Press:  15 May 2009

I. A. R. MacDonald ,
I. M. Gould  and
J. Curnow
I. A. R. MacDonald*
Affiliation:
Royal Aberdeen Children's Hospital, Cornhill Road, Aberdeen
I. M. Gould
Affiliation:
Department of Microbiology, Aberdeen Royal Infirmary NHS Trust, Aberdeen
J. Curnow
Affiliation:
Public Health Medicine, Woodend, Aberdeen
*
* Address for correspondence: Dr I. A. R. MacDonald, Department of Paediatrics, Peterborough District Hospital, Thorpe Road, Peterborough PE3 6BA.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A 3-year study of Escherichia coli infections in Grampian Region was conducted to ascertain the incidence, document clinical sequelae and identify at-risk groups. Approximately 30000 stools from patients with acute diarrhoea were screened for E. coli O157, and an epidemiological questionnaire filled in for each patient whose stool was positive. Eighty-three patients were studied. The annual incidence was 6 per 100000. Proportionately more infections occurred in people involved in agriculture. Evidence was seen of case-to-case transmission, and contamination of a water supply. Eight cases developed haemolytic uraemic syndrome (HUS). There were 2 deaths due to HUS and 2 due to haemorrhagic colitis (HC). Symptomatic E. coli infection is relatively common in the Grampian Region, more common in the agricultural community, and is the main cause of HUS in this Region.

Type
Special Article
Information
Epidemiology & Infection , Volume 116 , Issue 3 , June 1996 , pp. 279 - 284
Copyright
Copyright © Cambridge University Press 1996

References

REFERENCES

1.Ryan, CA, Tauxe, RV, Hosek, GW et al. , Escherichia coli O157:H7 diarrhoea in a nursing home: clinical, epidemiological, and pathological findings. J Infect Dis 1986; 154: 631–8.CrossRefGoogle Scholar
2.Carter, AO, Borczyk, AA, Carlson, JAK et al. , A severe outbreak of Escherichia coli O157:H7-associated hemorrhagic colitis in a nursing home. N Engl J Med 1987; 317: 1496–500.CrossRefGoogle ScholarPubMed
3.Morgan, GM, Newman, C, Palmer, SR et al. , First recognized community outbreak of haemorrhagic colitis due to verotoxin producing Escherichia coli O157:H7 in the UK. Epidemiol Infect 1988; 101: 83–91.CrossRefGoogle Scholar
4.Pai, CH, Ahmed, N, Lior, H, Johnson, WM, Sims, HV, Woods, DE. Verocytotoxin-producing Escherichia coli: a two year prospective study. J Infect Dis 1988; 157: 1054–7.CrossRefGoogle ScholarPubMed
5.Karmali, MA, Steele, BT, Petric, M, Lim, C. Sporadic cases of haemolytic uraemic syndrome associated with faecal cytotoxin and cytotoxin-producing Escherichia coli. Lancet 1983; i: 619–20.CrossRefGoogle Scholar
6.Karmali, MA, Petric, M, Lim, C, Fleming, PC, Arbus, GS, Lior, H. The association between hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli. J Infect Dis 1985; 151: 775–82.CrossRefGoogle ScholarPubMed
7.Scotland, SM, Rowe, B, Smith, HR, Willshaw, GA, Gross, RJ. Escherichia coli from children with haemolytic-uraemic syndrome and their detection by specific DNA probes. J Med Microbiol 1988; 25: 237–43.CrossRefGoogle ScholarPubMed
8.Karmali, MA. Infection by verocytotoxin-producing Escherichia coli. Clin Microbiol Rev 1989; 2: 15–38.CrossRefGoogle ScholarPubMed
9.Smith, HR, Scotland, SM. Verocytotoxin-producing strains of Escherichia coli. J Med Microbiol 1988; 26: 77–85.CrossRefGoogle Scholar
10.Tarr, PI, Neill, MA, Clausen, CR, Watkins, SL, Christie, DL, Hickman, RO. Escherichia coli O157:H7 and the hemolytic uremic syndrome: importance of early cultures in establishing the etiology. J Infect Dis 1990; 162: 553–6.CrossRefGoogle ScholarPubMed
11.Paterson, A, Gould, IM, Cashmore, C, Reid, TMS. Escherichia coli 0157 – One year's experience in Grampian. Comm Dis Scot Wkly Rep 1990; 243: 6–10.Google Scholar
12.Dev, VJ, Main, M, Gould, IM. Waterborne outbreak of Escherichia coli O157. Lancet 1991; 337: 1412.CrossRefGoogle ScholarPubMed
13.Hunt, CM, Harvey, JA, Youngs, ER, Irwin, ST, Reid, TM. Clinical and pathological variability of infection produced by enterohaemorrhagic (verocytotoxin producing) Escherichia coli. J Clin Pathol 1989; 42: 847–52.CrossRefGoogle Scholar
14.Sharp, JCM, Coia, JE, Curnow, J, Reilly, WJ. Escherichia coli 0157 infections in Scotland. J Med Microbiol 1994; 40: 1–6.Google Scholar
15.Chapman, PA, Wright, DJ, Norman, P. Verotoxin producing Escherichia coli infections in Sheffield: cattle as a possible source. Epidemiol Infect 1989; 102: 439–45.CrossRefGoogle ScholarPubMed
16.Read, SC, Gyles, CL, Clarke, RC, Lior, H, McEwen, S. Prevalence of verocytotoxigenic Escherichia coli in ground beef, pork and chicken in South West Ontario. Epidemiol Infect 1990; 105: 11–20.CrossRefGoogle Scholar
17.Renwick, SA, Wilson, JB, Clarke, RC et al. , Evidence of direct transmission of Escherichia coli O157:H7 infection between calves and a human. J Infect Dis 1993; 168; 792–3.CrossRefGoogle ScholarPubMed
18.Chapman, PA, Siddons, CA, Wright, DJ et al. , Cattle as a possible source of verocytotoxin producing Escherichia coli O157 infection in man. Epidemiol Infect 1993; 111: 439–47.CrossRefGoogle ScholarPubMed