Hostname: page-component-77c89778f8-cnmwb Total loading time: 0 Render date: 2024-07-20T02:17:37.665Z Has data issue: false hasContentIssue false
  • English
  • Français

The effects of morphine, diacetylmorphine and some related alkaloids upon the alimentary tract: Part II. Small intestine and ileo-colic sphincter

Published online by Cambridge University Press:  15 May 2009

G. Norman Myers
G. Norman Myers
Affiliation:
From the Pharmacological Laboratory, Cambridge
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The effects of morphine upon the small intestine are an increase in the tone and peristaltic movements. The frequency of peristaltic movements is slightly increased at first, but later decreased. The frequency of the rhythmical contractions remains more or less constant while their amplitude is increased. The tone and movements of the ileo-colic sphincter are increased.

2. Atropine modifies the effects of morphine by producing a decrease in tone and movements of the intestine, for varying periods of time. The subsequent injection of morphine during the period of inhibition produces, however, a further increase in tone and movements. Adrenalin causes a temporary inhibition of tone and movements after morphine.

3. Diacetylmorphine and dihydromorphinone produce similar effects; but are more active than morphine. Dihydromorphinone is approximately 10 times more active, and diacetylmorphine 11/2 times more active than morphine.

4. Dihydrocodeinone, codeine and dihydro-oxycodeinone produce similar effects to morphine but are much weaker, especially in so far as the production of increased tone is concerned. Regarding relative activities dihydrocodeinone lies between morphine and codeine, while dihydro-oxycodeinone is placed after codeinone.

Type
Research Article
Information
Journal of Hygiene , Volume 39 , Issue 4 , July 1939 , pp. 391 - 404
Copyright
Copyright © Cambridge University Press 1939

References

REFERENCES

Gruber, C. M. & Robinson, P. I. (1929). J. Pharmacol. 37, 101.Google Scholar
Krueger, H. (1933). J. Pharmacol. 50, 254.Google Scholar
Magnus, R. (1906). Pflüg. Arch. ges. Physiol. 115, 316.CrossRefGoogle Scholar
Magnus, R. (1908). Pflüg. Arch. ges. Physiol. 122, 210.Google Scholar
Mahlo, (1913). Dtsch. Arch. klin. Med. 110, 562.Google Scholar
Myers, G. N. (1934). J. Physiol. 81, 35.Google Scholar
Myers, G. N. (1933). Brit. med. J. 2, 372.CrossRefGoogle Scholar
Nothnagel, (1882). Virchows Arch. 79, 1.Google Scholar
Pal, (1900). Wien. med. Pr. 41, 2040.Google Scholar
Plant, O. H. & Miller, G. H. (1926). J. Pharmacol. 27, 361.Google Scholar
Rodari, (1909). Ther. Mh. (Halbmh.), 23, 540.Google Scholar
Schapiro, N. (1913). Pflüg. Arch. ges. Physiol. 151, 65.Google Scholar
Schwenter, R. (1912). Fortschr. Geb. Rontgenstr. 19, 1.Google Scholar
Spitzer, (1891). Virchows Arch. 123, 593.Google Scholar
Uhlmann, & Abelin, (1920). Z. exp. Path. Ther. 21, 58, 75.Google Scholar
Zehbe, M. (1913). Ther. Mh. (Halbmh.), 27, 406.Google Scholar
Zunz, E. (1909). Biochem. Zbl. 9, 208.Google Scholar