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Distribution of emm genotypes and superantigen genes of Streptococcus pyogenes isolated in Japan, 1994–9

Published online by Cambridge University Press:  18 July 2002

J. MURAKAMI ,
S. KAWABATA ,
Y. TERAO ,
K. KIKUCHI ,
K. TOTSUKA ,
A. TAMARU ,
C. KATSUKAWA ,
K. MORIYA ,
I. NAKAGAWA  and
I. MORISAKI
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J. MURAKAMI
Affiliation:
Department of Oral Microbiology, Osaka University Faculty of Dentistry, 1-8 Yamadaoka, Suita-Osaka 565-0871, Japan Division of Special Care Dentistry, Osaka University Faculty of Dentistry
S. KAWABATA
Affiliation:
Department of Oral Microbiology, Osaka University Faculty of Dentistry, 1-8 Yamadaoka, Suita-Osaka 565-0871, Japan
Y. TERAO
Affiliation:
Department of Oral Microbiology, Osaka University Faculty of Dentistry, 1-8 Yamadaoka, Suita-Osaka 565-0871, Japan
K. KIKUCHI
Affiliation:
Department of Infectious Diseases, Tokyo Women's Medical University, 8-1 Kawata-cho, Shinjuku-ku, Tokyo 162-8666, Japan
K. TOTSUKA
Affiliation:
Department of Infectious Diseases, Tokyo Women's Medical University, 8-1 Kawata-cho, Shinjuku-ku, Tokyo 162-8666, Japan
A. TAMARU
Affiliation:
Department of Microbiology, Osaka Prefectural Institute of Public Health, 1-3-69 Nakamichi, Higashinari-ku, Osaka 537-0025, Japan
C. KATSUKAWA
Affiliation:
Department of Microbiology, Osaka Prefectural Institute of Public Health, 1-3-69 Nakamichi, Higashinari-ku, Osaka 537-0025, Japan
K. MORIYA
Affiliation:
Department of Microbiology, Saga Prefectural Institute of Public Health, 1-20 Hacchonawate-cho, Saga 849-0925, Japan
I. NAKAGAWA
Affiliation:
Department of Oral Microbiology, Osaka University Faculty of Dentistry, 1-8 Yamadaoka, Suita-Osaka 565-0871, Japan
I. MORISAKI
Affiliation:
Division of Special Care Dentistry, Osaka University Faculty of Dentistry
S. HAMADA
Affiliation:
Department of Oral Microbiology, Osaka University Faculty of Dentistry, 1-8 Yamadaoka, Suita-Osaka 565-0871, Japan
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Abstract

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The purpose of this study was to examine characteristic profiles of Streptococcus pyogenes clinical isolates isolated in Japan during 1994–9. Genotyping of the M protein (emm typing) revealed that emm types 12 and 28 were the most common among 316 isolates. Most of the emm12 isolates were isolated from mucosa, while emm58 and emm89 were from skin. Moreover, the emm3 isolates were dominant in invasive infections. The distribution of 6 superantigen genes showed that all isolates harboured the mf gene and many had the speG gene. Invasive isolates were shown to have the ssa gene at a higher rate (76%) than noninvasive (37%). The distribution of superantigens was significantly different between emm types, but not between isolation sites. These results suggest that the distribution of emm types is related to isolation site, whereas superantigen distribution is related to clinical features of S. pyogenes infections.

Type
Research Article
Information
Epidemiology & Infection , Volume 128 , Issue 3 , June 2002 , pp. 397 - 404
Copyright
2002 Cambridge University Press