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Differing antibody responses to Haemophilus influenzae type b after meningitis or epiglottitis

Published online by Cambridge University Press:  15 May 2009

P. D. R. Johnson ,
M. Hanlon ,
D. Isaacs  and
G. L. Gilbert
P. D. R. Johnson
Affiliation:
Departments of Microbiology & Infectious Disease, Royal Children's Hospital, Parkville, Melbourne, Victoria 3052, Australia
M. Hanlon
Affiliation:
Immunology & Infectious Diseases, The Children's Hospital, Camperdown, Sydney, Australia
D. Isaacs
Affiliation:
Immunology & Infectious Diseases, The Children's Hospital, Camperdown, Sydney, Australia
G. L. Gilbert*
Affiliation:
Departments of Microbiology & Infectious Disease, Royal Children's Hospital, Parkville, Melbourne, Victoria 3052, Australia
*
* Current address: Department of Clinical Microbiology, Centre for Infectious Diseases and Microbiology, Westmead hospital, Westmead, N.S.W. 2145, Australia.
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Two common forms of invasive disease due to Haemophilus influenzae type b (Hib) are epiglottitis and meningitis. It is not known why some children develop epiglottitis and others meningitis. To examine the hypothesis that epiglottitis occurs in children who may have been previously exposed to Hib, and who would therefore exhibit a more vigorous antibody response in convalescence, we measured levels of antibody to Hib capsule in 92 children. Geometric mean convalescent-phase IgG, IgA, IgM and total antibody levels were significantly higher in 45 children with epiglottitis than in 47 with meningitis, even after adjustment for age differences (mean total antibody, 95% confidence intervals: meningitis 0·38, 0·34–0·43; epiglottitis: 2·25, 2·0–2·54 μg/ml). However, contrary to previous reports, a poor antibody response was only observed in a minority of children with meningitis; the antibody response of the majority was indistinguishable from that observed in children with epiglottitis.

Type
Research Article
Information
Epidemiology & Infection , Volume 116 , Issue 1 , February 1996 , pp. 21 - 26
Copyright
Copyright © Cambridge University Press 1996

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