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A Contribution to the Study of Amboceptors and Receptors. Third Communication on Heterologous Immunity to Malignant Mouse Tumours

Published online by Cambridge University Press:  15 May 2009

M. Tsurumi
M. Tsurumi
Affiliation:
(The Lister Institute of Preventive Medicine, London, S.W.)
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By using watery extracts of mouse tumours and guinea-pig kidney, and alcoholic goat erythrocyte extract, it has been shown that mouse tumour, guinea-pig kidney and goat erythrocyte antisera contain complement fixing antibodies for all three extracts, although the reaction is most evident when the homologous antigens are employed.

Goat erythrocyte antiserum agglutinates goat blood corpuscles strongly while guinea-pig kidney and mouse tumour sera do not contain haemagglutinin at all. Haemagglutination is therefore not to be regarded as a prelude to haemolysis; the antibodies for both processes can exist independently of one another. It has thus been seen that mouse tumour, guinea-pig kidney and goat erythrocytes have in common the property of producing, when inoculated into the rabbit, besides haemolytic amboceptors, complement fixing antibodies, but receptors for goat haemagglutinins cannot be found in either guinea-pig kidney or mouse tumours.

For his advice and assistance in carrying out this work I desire to thank Dr Schütze.

Type
Research Article
Information
Journal of Hygiene , Volume 15 , Issue 3 , September 1916 , pp. 365 - 371
Copyright
Copyright © Cambridge University Press 1916

References

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