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Contamination of Apparatus During Freeze-Drying

Published online by Cambridge University Press:  15 May 2009

D. Busby
D. Busby
Affiliation:
National Institute for Medical Research, Mill Hill, London, N.W. 7
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When the manifold system of freeze-drying is used the practice of plugging the tubes containing the product to be dried would seem to be necessary. It should be emphasized that a loose plug implies teased out cotton-wool and not just a loosely fitting one. Virus was recovered from the drying apparatus under various conditions when unplugged tubes were used. No virus contamination could be demonstrated when the tubes were plugged.

Type
Research Article
Information
Journal of Hygiene , Volume 57 , Issue 4 , December 1959 , pp. 403 - 406
Copyright
Copyright © Cambridge University Press 1959

References

REFERENCES

Flosdorf, E. W. & Mudd, S. (1935). Procedure and apparatus for preservation in ‘Lyophile’ form of serum and other biological substances. J. Immunol. 29, 389.CrossRefGoogle Scholar
Reitman, M., Moss, M. L., Harstad, J. B., Alg, R. L. & Gross, N. H. (1954). Potential infectious hazards of laboratory techniques. I. Lyophilization. J. Bad. 68, 541.Google Scholar
Stein, C. D. & Rodgers, H. (1950). Recovery of viable micro-organisms and viruses from vapours removed from frozen suspensions of biologic material during lyophilization. Amer. J. Vet. Res. 11, 339.Google Scholar