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The conglutination phenomenon. VIII. A. quantitative study of the components in six different complements essential for conglutination

Published online by Cambridge University Press:  15 May 2009

A. M. Blomfield
A. M. Blomfield
Affiliation:
Department of Pathology, University of Cambridge.
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1. A quantitative study has been made of the activity of C′1, C′2 and C′4 in the complements of the horse, cat, pig, man, guinea-pig and rabbit.

2. Evidence is presented which suggests that either there may be two types of C′4, the one haemolytic and the other conglutinating, or else that the manifestation of this complement component varies under conditions not yet understood.

3. In certain complements it appears that the serum proteins functioning as C′1 with the bovine anti-sheep red cell antibody are distinct from those functioning as C′1 with an antibody of similar specificity from an immune rabbit serum.

Type
Research Article
Information
Journal of Hygiene , Volume 50 , Issue 1 , March 1952 , pp. 126 - 135
Copyright
Copyright © Cambridge University Press 1952

References

REFERENCES

Bier, O. G., Leyton, G., Mayer, M. M., & Heidelberger, M. (1945). A comparison of human and guinea-pig complements and their component fractions. J. exp. Med. 81, 449.CrossRefGoogle ScholarPubMed
Blomfield, A. M., Coombs, R. R. A., & Hole, N. H. (1950). The conglutination phenomenon. VI. An experimental investigation of the factors determining the adsorption of comple-ment by an antigen-antiserum mixture. J. Hyg., Camb., 48, 73.CrossRefGoogle ScholarPubMed
Brand, H. (1907). Ueber das verhalten der Komplemente bei der Dialyse. Berl. klin. Wschr. 44, 1075.Google Scholar
Brown, G. C. (1943). The complement activity of mouse serum. J. Immunol. 46, 319.CrossRefGoogle Scholar
Coombs, R. R. A., & Hole, N. H. (1948). The congulationation phenomenon. IV. The importance of the choice of complement when examining antisera for the presence of complement-fixing or complement-absorbing antibodies. J. Hyg., Camb., 46, 296.CrossRefGoogle ScholarPubMed
Coombs, R. R. A., Blomfield, A. M., & Roberts, G. Fulton (1950). The conglutination phenomenon. VII. A study of the interaction of complement components and conglutinin in the process of conglutination. J. Hyg., Camb., 48, 484.Google ScholarPubMed
Cushing, J. E. (1945). A comparative study of complement. The interaction of components of different species. J. Immunol. 50, 75.CrossRefGoogle Scholar
Hagedüs, A., & Greiner, H. (1938). Quantitative bestimmung der Komplementbestand-teile. Z. Immun Forsch. 92, 1.Google Scholar
Manwarestg, W. H. (1906). On auxilysins; a preliminary communication. J. infect. Dis. 3, 225.Google Scholar
Pillemer, L., Eoker, E. E., Oncley, F. L., & Cohn, E. J. (1941). The preparation and physico-chemical characterisation of the serum protein components of complement. J. exp. Med. 74, 297.CrossRefGoogle Scholar
Rice, C. E. (1950a). The interchangeability of complement components of different species. III. In conglutination. J. Immunol. 65, 499.CrossRefGoogle ScholarPubMed
Rice, C. E. (1950b). Studies on the conglutinating complement-absorption test. I. With constant complement. Amer. J. vet. Res. 11, 98.Google Scholar
Whitehead, H. R., Gordon, J., & Wormall, A. (1925). The action of ammonia on complement; the fourth component. Biochem. J. 19, 618.CrossRefGoogle Scholar