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A comparison of complement-fixing antigens by Types 1 and 2 poliomyelitis-infected suckling mouse brains

Published online by Cambridge University Press:  15 May 2009

Golda Selzer
Golda Selzer
Affiliation:
C.S.I.R. and U.C.T. Virus Research Unit, Department of Pathology, University of Cape Town
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Good fixation of complement was obtained with the infective virus fraction of the Mahoney Type 1 poliomyelitis virus which had been adapted to suckling mice. The presence of a soluble antigen, specific to Type 1 virus, was also demonstrated but was small in amount.

The infective virus fraction of the suckling mouse adapted MEF1 Type 2 poliomyelitis virus produced as good fixation of complement as did Type 1, but the fixation of complement by the MEF1 soluble antigen was far greater than that obtained with the Mahoney strain.

The author would like to thank Prof. A. Kipps for his interest and encouragement and Miss M. Butchart for her valuable technical assistance. She is also indebted to Dr H. Malherbe of the Poliomyelitis Research Foundation, Johannesburg, for the Type 1 monkey immune serum.

Type
Research Article
Information
Journal of Hygiene , Volume 57 , Issue 3 , September 1959 , pp. 321 - 325
Copyright
Copyright © Cambridge University Press 1959

References

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