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Community studies on hepatitis B in Rajahmundry town of Andhra Pradesh, India, 1997–8: unnecessary therapeutic injections are a major risk factor

Published online by Cambridge University Press:  02 January 2001

J. SINGH
Affiliation:
National Institute of Communicable Diseases, 22 Shamnath Marg, Delhi-110054, India
R. BHATIA
Affiliation:
National Institute of Communicable Diseases, 22 Shamnath Marg, Delhi-110054, India
S. K. PATNAIK
Affiliation:
National Institute of Communicable Diseases, Regional Filaria Training and Research Centre, Weavers Colony, Rajahmundry-533105, Andhra Pradesh, India
S. KHARE
Affiliation:
National Institute of Communicable Diseases, 22 Shamnath Marg, Delhi-110054, India
D. BORA
Affiliation:
National Institute of Communicable Diseases, 22 Shamnath Marg, Delhi-110054, India
D. C. JAIN
Affiliation:
National Institute of Communicable Diseases, 22 Shamnath Marg, Delhi-110054, India
J. SOKHEY
Affiliation:
National Institute of Communicable Diseases, 22 Shamnath Marg, Delhi-110054, India
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Abstract

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In Rajahmundry town in India, 234 community cases of jaundice were interviewed for risk factors of viral hepatitis B and tested for markers of hepatitis A–E. About 41% and 1·7% of them were positive for anti-HBc and anti-HCV respectively. Of 83 cases who were tested within 3 months of onset of jaundice, 5 (6%), 11 (13·3%), 1 (1·2%), 5 (6%) and 16 (19·3%) were found to have acute viral hepatitis A–E, respectively. The aetiology of the remaining 60% (50/83) of cases of jaundice could not be established. Thirty-one percent (26/83) were already positive for anti-HBc before they developed jaundice. History of therapeutic injections before the onset of jaundice was significantly higher in cases of hepatitis B (P = 0·01) or B–D (P = 0·04) than in cases of hepatitis A and E together. Other potential risk factors of hepatitis B transmission were equally prevalent in two groups. Subsequent studies showed that the majority of injections given were unnecessary (74%, 95% CI 66–82%) and were administered by both qualified and unqualified doctors.

Type
Research Article
Copyright
© 2000 Cambridge University Press