Hostname: page-component-77c89778f8-fv566 Total loading time: 0 Render date: 2024-07-16T11:01:41.977Z Has data issue: false hasContentIssue false
  • English
  • Français

The Blood Volume in Ankylostomiasis. With some Biological Notes Relating to the Disease

Published online by Cambridge University Press:  15 May 2009

Willim Nicoll
Willim Nicoll
Affiliation:
Ernest Hart Memorial Scholar, British Medical Association.
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In these experiments the hook-worm anaemia of dogs does not appear to be exactly analogous to the corresponding disease in man, but differs from it in two essential particulars, namely, that only young animals suffer and that in them its course progresses much more rapidly to a fatal termination.

Older dogs, although not altogether insusceptible, acquire infection only to a moderate extent, which gives rise to a minor degree of anaemia. From this they gradually recover, even in spite of repeated and continued attempts at re-infection.

The anaemia in young dogs was characterised by great loss of weight, emaciation, prostration and intestinal haemorrhage, but in no case was expistaxis observed.

The blood volume of dogs suffering from the minor degree of hookworm anaemia is not materially altered, but if anything is somewhat diminished. The oxygen capacity of the blood per unit of body weight is also, on the average, somewhat decreased.

Infection is generally accompanied by distinct though not profuse haemorrhage, which is most marked in the early stages, but tends to disappear.

Eosinophilia was not a constant sign either of infection or of disease.

Evidence of blood regeneration was furnished by the appearance of large numbers of erythroblasts (normoblasts) which increased with the progress of the disease.

Cats are much less easily infected than dogs, and monkeys are altogether insusceptible. Man, also, were found to be insusceptible to infection with the dog hook-worm.

Type
Research Article
Information
Journal of Hygiene , Volume 13 , Issue 4 , January 1914 , pp. 369 - 392
Copyright
Copyright © Cambridge University Press 1913

References

REFERENCES

Abderhalden, E. and Schmid, J. (1910). Bestimmiung der Blutmenge mit Hilfe der “optischen Methods”. Zeitscher. f. Physiol. Chemine, LXVI. 120–127.CrossRefGoogle Scholar
Boycott, A.E. (1905). Ankylostomiasis. Trans. Epidem. Soc. London. N. S. XXIV. 25.Google Scholar
Boycott, A.E. (1911). The Milory Lectures on Ankylostoma Idfection. Lancet, Mar. 18th, 25th, and Apr. 1st, pp. 65. (Reprint.)Google Scholar
Botcott, A.E. (1912). The Size and Growth of the Blood in Rabbits. Journ. Path, and Bact. XVI. 485–501.Google Scholar
Boycott, A.E. and Haldane, J.S. (1903). An outbreak of Ankylostomiasis in England. Journ. of Hygiene, III. 95–136.Google Scholar
Castellani, A. (1910). Ankylostomiasis Fever. Journ. Trop. Med. and Hygiene, III. 255–258.Google Scholar
Dreyer, G. and Ray, W.G. (1910). The blood volume of Mammals as determined by experiments upon rabbits, guinea-pigs and mice and its relationship to the body weight and to the surface area expressed in a formula. Phil. Trans. Roy. Soc. B. 201, pp. 133–160.Google Scholar
Drever, G. and Ray, W. (1911). Further experiments upon the blood volume of Mammals and its relation to the surface area of the body. Phil. Trans. Roy. Soc. B. 202, pp. 191–212.Google Scholar
Grassi, B. (1978). Intorno ad una nuavo malattia del gatto, analoga alla clorosi d' Egitto del' uomo (Anemia da Anchilostoma). Gazz. Med. Italiano-Lombardo, Ser. 8a, III.Google Scholar
Gray, R.W. (1899). Ankylostomiasis in dogs. Brit. Med. Journ. P. 1107.Google Scholar
Jolyet, and Laffont, (1877). Bull. Soc. Biol. XXIX. 15.Google Scholar
Lambinet, J. (1905). Recherches sur la mode d'infection de I'organisme animal par les larves d'anchylostomes. Bull. Ac. roy. med. Blegique, XIX. 56–75.Google Scholar
Lifemann, H. (1905). Beitrag zum Studium der Ankylostomiasis; ueber den Infectionsmodus und die vermutliche Giftwirkung der Würmer. Zeitschr. F. Hygiene Und Infectionskrankh. L. 359–362.Google Scholar
Loeb, L. and Smith, A.J. (1904a). The presence of a substance inhibiting the coagulation of the blood in Ankylostoma. Proc. Path. Soc. Philad. N.S. VII. 173–177.Google Scholar
Loeb, L. and Smith, A.J. (1906). Über enie die Blutgerinnunghemmende Substanz in Ankylostsnz in Ankylostoma caninum. Centalbl. F. Bact. Orig. VII. 738–740.Google Scholar
Looss, A. (1911). The anatomy and life-history of A gchylostoma duodenale. Records School of Mediciene, Cairo, IV. 163–613.Google Scholar
Mégnin, J. (1882). Sur l'existence chez les chines de meute d'une anémie grave epidémique, sšaccompagant souvent d'epistaxis etc. Rec. méd. Vétér. Paris, LIX. 408–412.Google Scholar
Mégnin, J. (1883). Mémoire sur une anémie pernicieuse des chiens de meute, causée par un ankylostome aidée quelquefois d'un trichoceéphale. Rec. méd. Vétér. Paris, LX. 311–325.Google Scholar
Noc, F. (1908). Étude sur l'ankylostomiase etc. en Chchinchine. Ann. Inst. Pasteur, XXII. 896–916.Google Scholar
Panton, D.N.Gulland, G.L. and fowler, J.S. (1902). The relationship of the spleen to the formation of the blood corpuscles. Journ. of. Physicol. XXVIII. 83–106.Google Scholar
Preti, L. (1908). Haemolytische Wirkung von Ankylastoma duodenale. München. med. Wochenschr. LV. 436–437.Google Scholar
Railliet, A. (1882). Suite à la discussion sur l'anémie des meutes. Rec.Méd. Vétér. Paris, LIX. 416–417.Google Scholar
Ranke, J. (1871). Die Blutvertheilung und der Thütigkeitswechsel der orange.Google Scholar
Ransom, B.H. (1911). The nematodes parâsitic in the alimentary tract of cattle, sheep and other ruminants. U. S. Dept Agric, Bur. Anim. Indust. Bull. 127.Google Scholar
Siccardi, P.D (1910). Pathogénie de lˇanémie ankylostomienne. Arch. de Parasitol. XIII. 555–582.Google Scholar
Smith, J. and Lorrain, (1900). The volume and oxygen capacity of the blood in anaemia. Trans. Pathol. Soc. London, LI. 311–312.Google Scholar
Thrioux, and Terpaz, (1906). sur l'existence de Lˇankylostomise du chien au Sénégal. C. R. Soc. Biol. Paris, LIX. 265–266.Google Scholar
Trasbot, L. (1882). Suite â la dicussion sur l'aneémie des meutes. Rec. méd. Vétéer. Paris, LIX. 418–423.Google Scholar
Weinberg, M. and Leger, M. (1908). Recherches cliniques et expérimentellus sur L'ankylostomiase. Bull. Soc. Pathol. Exot. I. 229–233.Google Scholar
Whipple, G.H. (1908). Ankylostomiasis. Bull. Johns Hospital, XX. 152–153.Google Scholar
Whipple, G.H. (1909). The presence of a weak haemolysin in the hook-worm and its relation to the anaemia of uncinariasis. Journ. Exper. Medicine, New York, XI. 331–344.Google Scholar