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Binding to and antibacterial effect of aztreonam, temocillin, gentamicin and tobramycin on human faeces

Published online by Cambridge University Press:  19 October 2009

M. P. Hazenberg ,
A. M. Pennock-Schröder  and
J. P. van de Merwe
M. P. Hazenberg
Affiliation:
Department of Medical Microbiology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
A. M. Pennock-Schröder
Affiliation:
Department of Medical Microbiology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
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Aztreonam, temocillin, gentamicin and tobramycin were studied for their effect on the human faecal flora in vitro and for their usefulness for selective decontamination (SD) of the gastrointestinal tract. The sensitivities of the obligately anaerobic flora and the Gram-negative facultatively anaerobic bacteria were determined and the ratio was expressed as SD factor. Tho high SD factor of the flora from most subjects for aztreonam and tobramycin indicates that the drugs are useful for SD in contrast to temocillin and gentamicin. Binding to and subsequent release of tobramycin from faeces are presumed to facilitate the maintenance of adequate concentrations in the intestine despite the discontinuous intake.

Type
Research Article
Information
Journal of Hygiene , Volume 95 , Issue 2 , October 1985 , pp. 255 - 263
Copyright
Copyright © Cambridge University Press 1985

References

REFERENCES

Bennet, J. V., Brodie, J. L., Benner, E. J. & Kirby, W. M. M. (1966). Simplified accurate method for antibiotic assay of clinical specimens. Applied Microbiology 14, 170–177.CrossRefGoogle Scholar
Emmelot, C. H. & van der Waaij, D. (1980). The dose at which neomycin and polymyxin B can be applied for selective decontamination of the digestive tract in mice. Journal of Hygiene 69, 83–89.Google Scholar
Guiot, H. F. L., van den Broek, P. J., van der Meer, J. W. M. & van Furth, R. (1983). Selective antimicrobial modulation of the intestinal flora of patients with acute nonlymphocytic leukemia: a double blind, placebo-controlled study. Journal of Infectious Diseases 147, 615–623.CrossRefGoogle ScholarPubMed
Guiot, H. F. L. & van Furth, R. (1984). Selective antimicrobial modulation of the intestinal flora. Prophylaxis against infection in neutropenic patients. Infection 12, 1–4.CrossRefGoogle ScholarPubMed
Guiot, H. F. L., van der Meer, J. W. M. & van Furth, R. (1981). Selective antimocrobial modulation of human microflora: infection prevention in patients with decreased host defence mechanisms by selective elimination of potentially pathogenic bacteria. Journal of Infectious Diseases 143, 644–654.CrossRefGoogle Scholar
Hazenberg, M. P., Barker, M. & Verschoor-Burgoraaf, A. (1981). Effects of the human intestinal flora on germ-free mice. Journal of Applied Bacteriology 50, 95–106.CrossRefGoogle ScholarPubMed
Hazenberg, M. P., van de Boom, M., Barker, M. & van de Merwe, J. P. (1983 a). Effects of antibiotics on tho human intestinal flora in mice. Antonie van Leeuivenhoek 49, 97–109.CrossRefGoogle Scholar
Hazenberg, M. P., van de Boom, M., Barker, M. & van de Merwe, J. P. (1983 b). Binding to faeces and influence on human anaerobes of antimicrobial agents used for selective decontamination. Antonie van Leeuwenhoek 49, 111–117.CrossRefGoogle ScholarPubMed
Hazenberg, M. P., Pennocr-Schröder, A. M., van den Boom, M. & van de Merwe, J. P. (1984). Binding to and antibacterial effect of ampicillin, neomycin and polymyxin B on human faeces. Journal of Hygiene 93, 27–34.CrossRefGoogle ScholarPubMed
Kurrle, E., Bhaduri, S., Krieger, D., Pelieger, H. & Heimpel, H. (1983). Antimicrobial prophylaxis in acute leukaemia: Prospective randomized study comparing two methods of selective decontamination. Klinische Wochenschrift 61, 691–698.CrossRefGoogle ScholarPubMed
Sleijfer, D. Th., Mulder, N. H., de Vries-Hospers, H. G., Fidler, V., Nieweo, H. O., van der Waaij, D. & van Saene, H. K. F. (1980). Infection prevention in granulocytopenic patients by selective decontamination of tho digestive tract. European Journal of Cancer 16, 859–869.CrossRefGoogle Scholar
Slocombe, B., Basker, M. J., Bentley, P. H., Clayton, J. P., Cole, M., Comber, K. R., Dixon, R. A., Edmondson, R. A., Jackson, D., Merrikin, D. J. & Sutherland, R. (1981). BRL 17421, a novel p-lactam antibiotic, highly resistant to p-lactanmses, giving high and prolonged serum levels in humans. Antimicrobial Agents and Chemotherapy 20, 38–46.CrossRefGoogle Scholar
Swabb, E. A., Sugerman, A. A. & Stern, M. (1983). Oral bioavailability of the monobactam aztreonam (SQ 20, 776) in healthy subjects. Antimicrobial Agents and Chemotherapy 23, 548–550.CrossRefGoogle Scholar
de Vries-Hospers, H. G., Sleijfer, D. T., Mulder, N. H., van der Waaij, D., Nieweq, H. O. & van Saene, H. K. F. (1981). Bacteriological aspects of selective decontamination of the digestive tract as a method of infection prevention in granulocytopenic patients. Antimicrobial Agents and Chemotherapy 19, 813–820.CrossRefGoogle ScholarPubMed
de Vries-Hospers, H. G., Welling, G. W., Swann, E. A. & van der Waaij, D. (1984). Selective decontamination of tho digestive tract with aztreonam: as study of 10 healthy volunteers. Journal of Infectious Diseases 150, 636–642.CrossRefGoogle Scholar
van der Waaij, D. (1979). The colonization resistance of the digestive tract in experimental animals and its consequences for infection prevention, acquisition of new bacteria and the prevention of spread of bacteria between cage mates. In New Criteria for Antimicrobial Therapy: Maintenance of Digestive Trad Colonization Resistance (ed. Waaij, D. van der and Verhoeff, J.), pp. 43–53. Amsterdam: Excerpta Mcdica.Google Scholar
van der Waaij, D., Aberson, J., Thijm, H. A. & Welling, G. W. (1982). The screening of four aminoglycosides in tho selective decontamination of the digestive tract in mice. Infection 10, 35–40.CrossRefGoogle Scholar
Wagman, G. H., Bailey, J. V. & Weinstein, M. J. (1974). Binding of aminoglycosides to feces. Antimicrobial Agents and Chemotherapy 6, 415–417.CrossRefGoogle ScholarPubMed
Young, L. S. (1983). Antimicrobial prophylaxis against infection in neutropenic patients. Journal of Infectious Diseases 147, 611–614.Google ScholarPubMed