Hostname: page-component-77c89778f8-swr86 Total loading time: 0 Render date: 2024-07-18T13:12:00.244Z Has data issue: false hasContentIssue false
  • English
  • Français

The agglutinins of typhoid carriers

Published online by Cambridge University Press:  15 May 2009

Adrianus Pijper  and
C. G. Crocker
Adrianus Pijper
Affiliation:
From the authors' private laboratory, Pretoria, South Africa
C. G. Crocker
Affiliation:
From the authors' private laboratory, Pretoria, South Africa
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

By limiting our cultural investigations to persons who possess appreciable quantities of O agglutinins, we have detected a number of typhoid carriers and there are no indications that any carriers have been missed by following this labour-saving procedure. Several of our carriers were found to possess no H agglutinins.

As, however, O agglutinins occur in persons who are not carriers, and the number of such positive O reactors is increasing through the use of vaccines, the number of cultural examinations where no positive results can be expected is growing at a rate which will gradually make our procedure more difficult of application.

It would seem that Vi agglutination might provide a new and efficient method of narrowing down the field for cultural examinations. Vi agglutinins are very rare in normal persons. We have 4 manifest chronic carriers who possess significant quantities of Vi agglutinins. We have 3 persons who at one time were chronic stool carriers, in whom we now also find significant quantities of Vi agglutinins, but in whom at the time we cannot demonstrate typhoid bacilli. We also have 5 persons who at one time were chronic carriers, who now do not show any Vi agglutinins, and in whom we also at this time cannot find typhoid bacilli. Two of these were urinary carriers, which makes their negative cultural results more significant. Lastly, we have 2 persons who at one time obviously were temporary urinary carriers, and who now have lost their bacilli, and in whom also we now cannot detect Vi agglutinins.

In the search for typhoid carriers negative cultural results carry little weight. Our positive findings support the view that typhoid carriers are characterized by the possession of significant quantities of Vi agglutinins.

Type
Research Article
Information
Journal of Hygiene , Volume 37 , Issue 2 , April 1937 , pp. 332 - 339
Copyright
Copyright © Cambridge University Press 1937

References

Browning, C. H. et al. (1933). Spec. Rep. Ser., Med. Res. Counc. London, No. 179.Google Scholar
Cluver, E. H. (1936). Quart. Bull. Health Organ. League of Nat. 5, 1. Geneva.Google Scholar
Daubenton, F. (1931). J. Med. Assoc. S. Africa, 5, 71.Google Scholar
Eichhoff, E. (1932). Die Chirurgie der chronischen Typhus- und Paratyphusbazillenaus-scheider. Jena.Google Scholar
Felix, A. (1924). J. Immunol. 9, 115.Google Scholar
Felix, A., Krikorian, K. S. & Reitler, R. (1935). J. Hygiene, 35, 421.Google Scholar
Grasset, E. & Lewin, W. (1936). Brit. J. exp. Path. 17, 179.Google Scholar
Gundel, M. & Abdoosh, Y. B. (1936). Zbl. Bakter. I Orig. 136, 54.Google Scholar
Havens, L. C. (1935). The Bacteriology of Typhoid, Salmonella, and Dysentery Infections and Carrier States. New York.Google Scholar
Horgan, E. S. (1936). J. Hygiene, 36, 368.CrossRefGoogle Scholar
Pijper, A. (1930). J. Hygiene, 29, 380.Google Scholar
Pijper, A. & Dau, H. (1930). Brit. J. exp. Path. 11, 112.Google Scholar
Pijper, A. & Pullinger, B. D. (1928). Brit. Med. J. 1, 2.Google Scholar
Roesler, G. (1930). Das Schrifttum zur Frage der Typhus—und Paratyphusbazillenaus-scheider. Jena.Google Scholar
Topley, W. W. C. & Wilson, G. S. (1936). The Principles of Bacteriology and Immunity. London.Google Scholar