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Acute Bacillary Dysentery in Khartoum Province, Sudan, with Special Reference to Bacteriophage Treatment: Bacteriological Investigation

Published online by Cambridge University Press:  15 May 2009

D. Riding
D. Riding
Affiliation:
(Wellcome Tropical Research Laboratories, Khartoum.)
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1. Two preparations of bacteriophage were used for the treatment of a number of cases of acute bacillary dysentery.

2. The types of B. dysenteriae encountered in 60 cases of acute bacillary dysentery are described. In the 60 cases investigated the causal bacillus was bacteriophagable with the standard bacteriophage in vitro in 48.

3. The cases are tabulated and no dramatic results due to the bacteriophage treatment are demonstrated.

4. Treatment of the bacteriophage with hydrochloric acid, in a concentration similar to that of the gastric juice, for 60 minutes did not alter the virulence of the bacteriophage.

5. It is shown that 25 per cent, autoclaved intestinal mucus in normal saline, and human blood serum, not inactivated, compare unfavourably with laboratory broth as a medium for bacteriophage action.

6. The results of giving bacteriophage by mouth to normal individuals, and to dysentery patients are described and discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 30 , Issue 3 , August 1930 , pp. 387 - 401
Copyright
Copyright © Cambridge University Press 1930

References

REFERENCE

d'Herelle, (1926). The Bacteriophage and its Behaviour. English transl.Google Scholar